grant
Rational Design of Artificial Hydrogenases
Organization UNIVERSITY OF MISSISSIPPILocation UNIVERSITY, UNITED STATESPosted 20 Sept 2018Deadline 1 Sept 2028
NIHUS FederalResearch GrantFY20253-Mercapto-D-valineActive SitesAddressBeta-thiovalineBindingBioinorganic ChemistryBiotechBiotechnologyCarbonChemistryClosure by LigationComplexD-3-MercaptovalineD-MercaptovalineDepamineDependenceDevelopmentDimethylcysteineElectron TransportElectronsEnvironmentEnzyme GeneEnzymesEquilibriumEvolutionFutureGasesGoalsH+ elementH-bondHydrogen BondingHydrogen IonsHydrogen OxideHydrogenaseHydrogenlyaseHydrophobicityIndividualKineticsLabelLengthLigandsLigationMentorsMercaptansMercapto CompoundsMercaptovalineMetalloproteinsMetallothioneinMetalsMississippiModelingMolecular InteractionMononuclearNatural GasNatural ResourcesNegative Beta ParticleNegatronsNuclearOrganismOutcome StudyOxidation-ReductionPathway interactionsPenicillaminePeptidesProcessProductionPropertyProtein EngineeringProteinsProteomicsProtonsRedoxResearchRoleScaffolding ProteinScienceSecurityShapesSiteSpectroscopySpectrum AnalysesSpectrum AnalysisStructureSulfhydryl CompoundsSunlightSystemThiolsTrainingTranslatingUniversitiesWaterWorkabsorptionalkalinityanalogbalancebalance functionbasicitybeta,beta-Dimethylcysteinebiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquescarbon emissionscareercatalystcofactorconformerdesigndesigningdevelopmentaldimerelectron transferexpectationfinessefunctional improvementgenetic protein engineeringgraduate studentimprove functionimproved functional outcomesinsightliving systemmetallicitymetalloenzymenon-natural amino acidsnon-proteinogenic amino acidsnonproteinogenic amino acidsnoveloxidationoxidation reduction reactionpathwaypreferenceprogramsprotein designprotonationrational designscaffoldscaffoldingsmall moleculesocial rolesulfhydryl groupsun lightundergradundergraduateundergraduate studentunnatural amino acids
Description preview
PROJECT SUMMARY/ABSTRACT
Hydrogenases are complex metalloenzymes that generate energy for certain organisms or balance cellular
redox potentials by catalyzing the reversible interconversion between H2 oxidation and H+ reduction,
respectively. Unraveling the intricate details of the function of these enzymes will significantly advance H2-
based,…
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