grant
RARE and Atypical Diabetes Network(RADIANT)
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 10 Sept 2018Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025Adult-Onset Diabetes MellitusAgeAutoantibodiesAutoimmuneBlood PlasmaBrittle Diabetes MellitusCategoriesCausalityCell modelCellular modelCharacteristicsClassificationClinicalConfusionConfusional StateD-GlucoseDNA mutationDataData BasesDatabasesDescriptorDextroseDiabetes MellitusDiabetes mellitus syndrome in newborn infantDiagnosisDiagnosticDiseaseDisorderDrug TargetingDysfunctionElementsEnrollmentEtiologyFamilyFamily memberFunctional disorderFundingGene variantGenesGenetic ChangeGenetic defectGenetic mutationGenomeGenomicsGenotypeGlucoseGoalsHumanHumulin RHyperglycemiaIDDMIndividualInfrastructureInsulinInsulin ResistanceInsulin deficiencyInsulin-Dependent Diabetes MellitusInvestigatorsJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusMaturity-Onset Diabetes MellitusMediatingMental ConfusionModelingModern ManMolecularMutationNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityPancreatic beta CellPancreatic β-CellParticipantPathogenicityPathologicPathway interactionsPatientsPersonsPhenotypePhysiologicPhysiologicalPhysiologyPhysiopathologyPlasmaPlasma SerumProcessRNA SeqRNA sequencingRNAseqRegular InsulinResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaSlow-Onset Diabetes MellitusSourceStable Diabetes MellitusStructure of beta Cell of isletSubgroupSudden-Onset Diabetes MellitusSyndromeSystematicsT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTherapeuticType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesVariantVariationWorkadiposityadjudicationadjudicative process and procedureadult onset diabetesagesallelic variantautoimmune antibodyautoreactive antibodycausationcorpulencedata basedepositorydiabetesdiagnostic criteriadisease causationeligible participantenrollentire genomefallsfamily geneticsfull genomegenetic variantgenome mutationgenome sequencinggenomic variantglobal gene expressionglobal transcription profilehyperglycemiciPSiPSCiPSCsimprovedinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinsulin dependent diabetesinsulin dependent type 1insulin resistantinsulin tolerancejuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabeteslean body massloss of function mutationmaturity onset diabetesmetabolism measurementmetabolomicsmetabonomicsmultidisciplinaryneonatal diabetesneonatal diabetes mellituspancreas beta cellpancreas β cellpancreatic b-cellparticipant enrollmentpathophysiologypathwaypatient enrollmentpersonalized diagnosispersonalized diagnosticsprecise diagnosticsprecision diagnosticspublic health relevancerecruitrepositoryresponsescreeningscreeningsself reactive antibodythymus derived lymphocytetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstype 2 DMtype I diabetestype II DMtype one diabetestype two diabeteswhole genome
Description preview
Diabetes is traditionally classified in two broad categories: autoimmune Type 1 and obesity-related Type 2. Numerous phenotypically and etiologically distinct forms exist and are emerging, collectively termed “atypical diabetes”, that do not fit into either category. We hypothesize that atypical diabetes comprises a spectrum that includes numerous…
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