grant
Rapid Diagnosis of Ocular Infections using a Sensitive and Highly Multiplexed Broad Pathogen Detection Assay
Organization MASSACHUSETTS EYE AND EAR INFIRMARYLocation BOSTON, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AddressAdoptionAntimicrobial ResistanceAssayBioassayBiological AssayBlindnessBody TissuesCancersCausalityCell Communication and SignalingCell SignalingCharacteristicsClinicalClinical ManagementClinical assessmentsCollectionCommunicable DiseasesComplex MixturesConsumptionCorneaCorneal infectionDNADeoxyribonucleic AcidDetectionDevelopmentDiagnosisDiagnosticDiagnostic testsDrugsEarly identificationEndophthalmitisEquilibriumEtiologyEyeEye InfectionsEyeballGeographyGoalsHourIndividualInfectionInfectious DiseasesInfectious DisorderIntracellular Communication and SignalingKeratitisLaboratoriesLaboratory DiagnosisMalignant NeoplasmsMalignant TumorMedical centerMedicationMethodsMicrobial keratitisMorbidityMorbidity - disease rateNoiseNon-Polyadenylated RNANucleic AcidsOcular InfectionsOphthalmiaOphthalmologyPathogen detectionPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPerformancePharmaceutical PreparationsPublishingRNARNA Gene ProductsReactionReportingResearch SpecimenResistanceRibonucleic AcidSamplingSensitivity and SpecificitySightSignal TransductionSignal Transduction SystemsSignalingSpecimenSpeedTechnologyTestingTimeTissuesToxic effectToxicitiesTranslatingUveitisValidationVisionWorkaccurate diagnosisanti-microbialanti-microbial resistance emergenceanti-microbial resistantantimicrobialantimicrobial resistance emergencebalancebalance functionbiobankbiological signal transductionbiorepositorycausationclinical implementationclinical validationclinically actionablecornealcostdepositorydesigndesigningdetection assaydevelopmentaldiagnostic approachdiagnostic platformdiagnostic strategydiagnostic systemdisease causationdrug/agenteffective therapyeffective treatmentemerging anti-microbial resistanceemerging antimicrobial resistanceeye toxicityimprovedimproved outcomeinfections in the corneainfectious keratitisinnovateinnovationinnovativemalignancymetagenome sequencingmetagenomic sequencingmolecular diagnosticsnanostringneoplasm/cancernew diagnosticsnext generation diagnosticsnovelnovel diagnosticsocular toxicitypathogenpatient oriented outcomesperformance testspersonalized diagnosispersonalized diagnosticsprecise diagnosticsprecision diagnosticsprospectiverapid diagnosisrepositoryresistance to anti-microbialresistantresistant to antimicrobialretinal toxicityvalidationsvision lossvisual functionvisual loss
Description preview
PROJECT SUMMARY
Timely and accurate diagnosis of ocular infections is critical to support early effective therapy and save vision.
Serious infections such as infectious keratitis, uveitis and endophthalmitis are leading causes of blindness
globally. These infections are caused by a wide range of pathogens, which can often present with overlapping…
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