grant
Radiogenomic Predictors of Treatment Response in Head and Neck Squamous Cell Carcinoma
Organization UNIVERSITY OF KANSAS MEDICAL CENTERLocation KANSAS CITY, UNITED STATESPosted 15 Feb 2019Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025ATP-protein phosphotransferaseAddressAdoptedAfter CareAfter-TreatmentAftercareAtlasesBiologicalBiological MarkersBiomedical EngineeringBiopsyBlood PlasmaCancer ModelCancerModelCancersCharacteristicsClinicalClinical TrialsCollaborationsCore FacilityDataData BasesData SetDatabasesDevelopmentDisease ProgressionEGF ReceptorEGFRERBB ProteinEarly InterventionEarly identificationEarly treatmentEnsureEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsExtracellular Signal-Regulated Kinase GeneFeasibility StudiesFormalinFoundationsFutureGene ExpressionGene TranscriptionGenesGenetic TranscriptionGenomicsGoalsHER1HNSCCHPVHPV(-) HNSCCHPV(-) head and neck squamous cell carcinomaHPV- HNSCCHPV-negative HNSCCHPV-negative head and neck cancerHPV-negative head and neck squamous cell carcinomaHead and Neck CancerHead and Neck CarcinomaHead and Neck Squamous Cell CarcinomaHuman Papilloma VirusHuman PapillomavirusHypoxia PathwayHypoxia and p53 in the Cardiovascular systemImageIndividualInfectious Human Wart VirusInstitutionInvestigationKansasKinase Family GeneLiquid substanceMAP Kinase GeneMAPKMachine LearningMalignant Head and Neck NeoplasmMalignant NeoplasmsMalignant TumorMeasurementMeasuresMediatingMedicalMedical centerMethodologyMitogen-Activated Protein Kinase GeneModelingMolecularMultiomic DataNeckNetwork-basedOperative ProceduresOperative Surgical ProceduresOutcomePapilloma VirusesPapillomaviridaePapillomavirusParaffin EmbeddingPathologicPatient CarePatient Care DeliveryPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypePlasmaPlasma SerumPrecision carePrecision medicine trialPrecision therapeuticsPrediction of Response to TherapyPrognostic MarkerProgression-Free SurvivalsProtein KinaseRNA ExpressionRadiogenomicsRadiographyRecurrenceRecurrentResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRoentgenographySCCHNSamplingSurgicalSurgical InterventionsSurgical ProcedureTCGATCIATGF-alpha ReceptorTestingThe Cancer Genome AtlasThe Cancer Imaging ArchiveTissue EmbeddingTrainingTranscriptionTransforming Growth Factor alpha ReceptorTreatment FailureTreatment PeriodTreatment outcomeTumor CellTumor TissueTumor-DerivedUniversitiesUrogastrone ReceptorWorkbio-engineeredbio-engineersbio-markersbiobankbioengineeringbiologicbiologic markerbiological engineeringbiomarkerbiomarker identificationbiomarker validationbiorepositoryc-erbB-1c-erbB-1 Proteincancer genomicscancer imagingcancer progressioncare for patientscare of patientscaring for patientschemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapycirculating tumor DNA assaycirculating tumor DNA assessmentcirculating tumor DNA evaluationcirculating tumor DNA monitoringcirculating tumor DNA profilingcirculating tumor DNA screeningcirculating tumor DNA testingclinical relevanceclinically relevantcommunity engagementcontrast CTcontrast enhanced CTcontrast enhanced computed tomographyctDNA assayctDNA assessmentctDNA evaluationctDNA monitoringctDNA profilingctDNA screeningctDNA testingdata basedesigndesigningdevelopmentaldigitalearly therapyengagement with communitieserbB-1erbB-1 Proto-Oncogene ProteinerbBlfluidglobal gene expressionglobal transcription profileglycogen synthase a kinasehead and neck squamous carcinomahead and neck squamous cell cancerhead/neck cancerhigh riskhuman papillomavirus (-) head and neck squamous cell carcinomahuman papillomavirus - head and neck squamous cell carcinomahuman papillomavirus negative head and neck cancerhuman papillomavirus negative head and neck squamous cell carcinomahuman papillomavirus- head and neck squamous cell carcinomahydroxyalkyl protein kinaseidentification of biomarkersidentification of new biomarkersimagingimprovedindividualized careindividualized patient careliquidmachine based learningmachine learning based modelmachine learning modelmalignancymalignant head and neck tumormarker identificationmarker validationmultidisciplinarymultiomicsmultiple omic datamultiple omicsneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionneural networknon-HPV HNSCCnon-human papillomavirus head and neck squamous cell carcinomanoveloncogenomicsoncologic imagingoncology imagingoutcome predictionoutreach programpanomicsparticipant engagementpatient biomarkerspatient centeredpatient engagementpatient orientedpatient oriented outcomespatient outreachpersonalized carepersonalized patient carephosphorylase b kinase kinasepost treatmentprecision medicineprecision therapiesprecision treatmentprecision-based medicinepredict therapeutic responsepredict therapy responseprognosis modelprognosticprognostic biomarkerprognostic indicatorprognostic modelprospectiveproto-oncogene protein c-erbB-1quantitative imagingradio-chemo-therapyradio-chemotherapyradiochemotherapyradiological imagingradiomicsresponse to therapyresponse to treatmentsurgerysurvival predictiontargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy failuretherapy predictiontherapy responsetranscriptometranscriptomicstreatment daystreatment durationtreatment predictiontreatment responsetreatment response predictiontreatment responsivenesstumortumor DNAtumor cell DNAtumor imagingtumor progressiontumor-specific DNAwart virus
Description preview
PROJECT SUMMARY/ABSTRACT
Despite recent advances in the treatment of head and neck squamous cell carcinoma (HNSCC), five-year overall
survival (OS) has remained poor due to high rates of disease progression after treatment. A lack of reliable
prognostic biomarkers limits our ability to predict disease progression in non-human papillomavirus…
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