grant
Radical SAM Enzymes: Radical Mechanisms Central to Biology
Organization MONTANA STATE UNIVERSITY - BOZEMANLocation BOZEMAN, UNITED STATESPosted 1 Jun 2019Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AD dementiaAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAntibiotic AgentsAntibiotic DrugsAntibioticsBiochemicalBiologicalBiologyChemicalsComplexDNA Damage RepairDNA RepairDiseaseDisorderENDOREPR spectroscopyESR SpectroscopyElectron Nuclear Double ResonanceElectron Paramagnetic ResonanceElectron Spin ResonanceElectron Spin Resonance SpectroscopyEnzyme GeneEnzymesFreezingGoalsHumanIndividualInfectionLifeMetalsMiscellaneous AntibioticModern ManModificationPF-lyase activating enzymePFL activaseParamagnetic ResonancePeptidesPfl activating enzymePharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePrimary Senile Degenerative DementiaProcessPropertyProteinsReactionResearchRibosomesSingle Crystal DiffractionSystemTherapeutic AgentsUnscheduled DNA SynthesisX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographybeneficial florabeneficial microbesbeneficial microflorabeneficial microorganismbiologiccatalystchemical propertychemical reactioncofactorelectron paramagnetic resonance spectroscopyformate acetyltransferase activating enzymeinsightmembermicrobe pathogenmicrobial pathogenpathogenic microbepharmaceuticalprimary degenerative dementiapyruvate formate-lyase activating enzymepyruvate-format-lyase activating enzymesenile dementia of the Alzheimer typetime usetool
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Summary / Abstract
Radical SAM is the largest enzyme superfamily known, with its members catalyzing a remarkable diversity
of reactions in all domains of life. Radical SAM enzymes are involved in the synthesis of essential cofactors
and antibiotics, repair of DNA damage, and the assembly of complex biological metal clusters, among
many other…
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