grant
Rac1 and the actin cytoskeleton in renal tubular repair
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Jul 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DActinsActomyosinAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyApicalArchitectureAutoregulationBiological FunctionBiological ProcessBody TissuesCDC2CDC2 Protein KinaseCDC2 geneCDK1Cell BodyCell Culture TechniquesCell CycleCell Cycle ControlCell Cycle Controller CDC2 GeneCell Cycle Controller cdc2Cell Cycle ProgressionCell Cycle RegulationCell DeathCell Division Control Protein 2 HomologCell Division CycleCell Division Cycle 2Cell Division Cycle 2 ProteinCell Growth in NumberCell MultiplicationCell ProliferationCell ShapeCell divisionCell membraneCellsCellular MatrixCellular MorphologyCellular ProliferationChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureComplexCyclin BCyclin-Dependent Kinase 1Cytoplasmic MembraneCytoskeletal ModelingCytoskeletal OrganizationCytoskeletal Organization ProcessCytoskeletal ReorganizationCytoskeletal SystemCytoskeletonDataDefectDevelopmentDuctDuct (organ) structureDuct EpitheliumDuctal EpitheliumDysmorphologyERM proteinETV5 proteinElectrolytesEngineering / ArchitectureEpithelial CellsEpitheliumEts-related molecule PEA3-like proteinF-ActinFilamentous ActinG2/M TransitionHistologicHistologicallyHomeostasisHydrogen OxideIn VitroInjuryIschemiaKidneyKidney DiseasesKidney TubulesKidney Urinary SystemKinasesKnowledgeLeadM PhaseM cellMechanicsMediatingMitosisMitosis StageMitoticModelingMolecularMolecular Dynamics SimulationMorphologyNatural regenerationNephropathyNutrientObstructionOpticsPb elementPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPlasma MembranePlayProcessProliferatingProteinsRegenerationRenal DiseaseRenal tubule structureReperfusion TherapyResolutionRoleShapesTestingTissuesTransphosphorylasesTubeTubularTubular formationWaterWorkacute kidney injurycdc13 Proteincdc2 gene productcdc2+ Proteincdk1 Kinasecell culturecell culturescell morphologychronic kidney diseasedevelopmentalepithelial repairepithelium regenerationheavy metal Pbheavy metal leadhigh resolution imagingin vivoinjuriesintracellular skeletonkidney disorderkidney repairlaser capture microdissectionlive cell imagelive cell imaginglive cellular imagelive cellular imagingmechanicmechanicalmolecular dynamicsmutantnecrocytosisnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetopticalp21 activated kinasep34 Protein Kinasep34 Protein Kinase Genep34(CDC2) Genep34CDC2p56cdc13plasmalemmapressureregenerateregenerate epitheliumrenalrenal disorderrenal epitheliumrenal tubulerepairrepairedreperfusionresolutionsrho G-Proteinsrho GTP-Binding Proteinsrho GTPasesrho Protein P21rho Small GTP-Binding Proteinssocial rolespatial and temporalspatial temporalspatiotemporalsuperresolution imagingthree dimensionaltissue repair
Description preview
Polarized epithelial tubes are critical for an intact kidney. They control water, electrolyte, and nutrient
homeostasis, all of which are deranged in chronic kidney disease. These specialized epithelia require a highly
organized actin cytoskeleton that determines cellular shape and function. During renal epithelial repair, the actin
cytoskeleton…
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