grant
Quantitative Systems Pharmacology of Antibody Therapeutics across Diverse Biological Contexts
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AddressAnimalsAntibodiesAntibody TherapyBindingBiologic ModelsBiologicalBiological ModelsBioluminescenceBiophysicsBody TissuesCell BodyCell CommunicationCell InteractionCell modelCell-to-Cell InteractionCellsCellular modelConstant RegionCoupledDataDevelopmentDimensionsDiseaseDisorderDrug KineticsDrugsEnergy TransferEnvironmentExhibitsIg Constant RegionImaging DeviceImaging InstrumentImaging ToolImaging technologyImmuneImmunesImmunoglobulin Constant RegionMathMathematicsMeasuresMediatingMedicationMethodsModel SystemModelingMolecular InteractionPK/PDPathologyPharmaceutical PreparationsPharmacokineticsPharmacologic ActionsPharmacologyPhysiologicPhysiologicalPhysiologyProcessResearchRoleSystemTherapeuticTherapeutic antibodiesTissuesTranslationsVariantVariationWorkantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentbiologicbiophysical foundationbiophysical principlesbiophysical sciencescell imagingcellular imagingdesigndesigningdevelopmentaldrug developmentdrug/agentimaging approachimaging based approachimmunological statusin vivoinsightmolecular imagingmolecule imagingneglectpatient populationpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespharmacokinetics and pharmacodynamicsrapid growthsocial rolespatial and temporalspatial temporalspatiotemporalsuccesstherapeutic agent developmenttherapeutic developmenttooltranslation
Description preview
ABSTRACT
Antibody-based therapeutics have grown rapidly over the past two decades. However, many challenges limiting
the success of this drug class persist. First, the attrition rate remains high in antibody drug development. Second,
many antibody therapeutics exhibit only transient pharmacologic action. As a result, antibody therapeutics benefit…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click