grant
Quantifying neural signatures of multi-step avoidance behavior in anxiety
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectiveAnimalsAnxietyAnxiety DisordersAssayAutomobile DrivingBehaviorBehavioralBehavioral AssayBioassayBiological AssayBiological MarkersBrainBrain Nervous SystemCategoriesClinicalCognitiveComplexComputer ModelsComputerized ModelsDataDiagnosticDiseaseDisorderEncephalonEthologyFunctional MRIFunctional Magnetic Resonance ImagingGeneticGoalsHumanImpairmentIntervention StrategiesLaboratoriesLearningLinkMeasuresMental disordersMental health disordersModelingModern ManMolecularNIMHNational Institute of Mental HealthNerve Impulse TransmissionNerve TransmissionNeuronal TransmissionOrganismOutcomeOutputParticipantPatient Self-ReportPatternPersonsPhysiologicPhysiologicalPreventiveProcessPsychiatric DiseasePsychiatric DisorderPsychological reinforcementPsychopathologyReinforcementResearchScanningSelf-ReportSeveritiesStrategic PlanningStructureSystemTestingTherapeuticTrainingTranslatingTreatment outcomeabnormal psychologyadulthoodanxiety symptomsanxiety-related disordersanxious symptomavoidance behavioraxon signalingaxon-glial signalingaxonal signalingbehavior predictionbehavioral predictionbio-markersbiologic markerbiomarkerclinical anxietycomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingdevelop therapydrivingfMRIfMRI scanfunctional MRI scanfunctional magnetic resonance imaging scanglia signalingglial signalingimprovedinterdisciplinary approachintervention developmentliving systemmental illnessmultidisciplinary approachneglectnerve signalingneuralneural circuitneural circuitryneural modelneural patterningneural signalingneurocircuitryneuronal signalingneurophysiologicalneurophysiologyneurotransmissionnew approachesnovelnovel approachesnovel strategiesnovel strategypredictive modelingpreservationpsychiatric illnesspsychologicpsychologicalpsychological disordersocialsynaptic circuitsynaptic circuitrytheoriestherapy developmenttranslation assaytranslational modeltreatment development
Description preview
Anxiety and related disorders are common and impairing; in particular, avoidance is a highly detrimental
component of anxiety that is poorly understood. To better understand and treat avoidance, a theory of
avoidance that can account for experimental findings and translate across species is needed. This application
proposes to use an…
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