grant
Quantifying cerebellar multi-omic and synaptic features of autism spectrum disorders
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 1 Apr 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY202621+ years oldASDAddressAdultAdult HumanAgeAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAutismAutistic DisorderAutopsyBaltimoreBehavior-Related DisorderBehavior-Related ProblemBody TissuesBourneville DiseaseBourneville PhakomatosisBourneville syndromeBourneville-Brissaud diseaseBourneville-Pringle syndromeBrainBrain Nervous SystemCell BodyCell NucleusCellsCerebellar vermis structureCerebellumCerebroatrophic HyperammonemiaChromatinChromosome MappingCognitionDNA mutationDataData SetDendritesDevelopmentDiagnosisEarly Infantile AutismEmotionalEncephalonEpiloiaEscalante syndromeFiberFragile XFragile X SyndromeGene Action RegulationGene Down-RegulationGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene Expression RegulationGene LocalizationGene MappingGene Mapping GeneticsGene OrganizationGene RegulationGene Regulation ProcessGene StructureGene Structure/OrganizationGene TranscriptionGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGliaGlial CellsHamartinHeterogeneityHumanImageIndividualInfantile AutismKO miceKanner's SyndromeKnock-out MiceKnockout MiceKnowledgeKolliker's reticulumLifestyle-Related DisorderLifestyle-Related ProblemLifestyle-related conditionLinkage MappingLoxP-flanked alleleMartin-Bell SyndromeMartin-Bell-Renpenning syndromeMarylandMiceMice MammalsMicroscopyModern ManMorphologyMurineMusMutationNanostructuresNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronsNon-neuronal cellNonneuronal cellNucleusNull MouseOutputPhenotypePhysiologyPopulationPringle diseasePurkinje CellsPurkinje's CorpusclesRNA ExpressionRenpenning syndrome 2Research ResourcesResearch SpecimenResourcesRett DisorderRett SyndromeRisk-associated variantRoleSamplingSingle-Nucleus SequencingSocial BehaviorSpecimenStructureSubgroupSynapsesSynapticTSC1TSC1 geneTestingTissue BanksTissue CollectionTissue SampleTissue repositoryTissuesTotal Human and Non-Human Gene MappingTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription RepressionTranslatingTuberous SclerosisUniversity resourcesX-linked mental deficiency-megalotestes syndromeX-linked mental retardation with fragile X syndromeX-linked mental retardation-fragile site 1 syndromeadenoma sebaceumadulthoodagesanalyze gene expressionautism attributesautism indicatorautism modelautism spectral disorderautism spectrum disorderautism spectrum disorder featuresautism spectrum disorder indicatorautism spectrum disorder symptomsautism symptomologyautism symptomsautism-fragile X (AFRAX) syndromeautism-like symptomsautism-related attributesautistic featuresautistic individualsautistic peopleautistic spectrum disorderautistic symptomsautistic traitsautistic-like symptomsbrain tissuecausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell imagingcell typecellular imagingcerebellar Purkinje cellcerebral sclerosiscohortconditional knock-outconditional knockoutconfocal imagingdensitydevelopmentalepigenomicsepiploiaexperimentexperimental researchexperimental studyexperimentsfloxedfloxed allelefra(X) syndromefra(X)(28) syndromefra(X)(q27) syndromefra(X)(q27-28) syndromefragile X-mental retardation syndromefragile Xq syndromefragile site mental retardation 1functional statusgene expression analysisgene expression assaygene networkgene regulatory networkgene repressiongenes structuregenetic mappinggenome mutationglobal gene expressionglobal transcription profilegranule cellhereditary multiple system hamartomatosishuman dataimagingimaging studyindividuals on the autism spectrumindividuals on the spectrumindividuals with ASDindividuals with autismindividuals with autism spectrum disorderinsightmacro-orchidism-marker X (MOMX) syndromemacro-orchidism-marker X syndromemar(X) syndromemarker X syndromemental retardation-macroorchidism syndromemodel of animalmodel of autism spectrum disordermouse modelmultiomicsmultiple omicsmurine modelnano meter scalenano meter sizednano-sized structuresnano-structuresnanometer scalenanometer sizednanoscalenecropsyneocorticalnerve cementnetwork modelsneurinomatosis centralisneurobiological mechanismneuromatosis universalisneuronalneuropathologicneuropathologicalneuropathologyneurospongioblastosis diffusanew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpanomicspeople on the autism spectrumpeople with ASDpeople with autismpeople with autism spectrum disorderphacomatosispostmortempostsynapticpublic health relevancerisk allelerisk generisk genotyperisk locirisk locusrisk variantsNuc-Seqsclerosis tuberosasexsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesociobehaviorsociobehavioralspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspongioblastosis circumscriptasuper high resolutionsuperresolutionsynapsesynapse functionsynaptic functiontraittranscriptional profilingtranscriptometranscriptomicstuberose sclerosistuberous sclerosis 1tuberous sclerosis complexultra high resolutionultra resolutionultrafine resolutionvermis
Description preview
Project Summary
Strong, longstanding evidence points to important roles for the cerebellum in autism spectrum disorders (ASDs),
yet cerebellar mechanisms remain understudied in ASDs compared to neocortical circuits. Anatomical and
functional studies have pointed, in particular, to changes in the synapses of Purkinje cells, the sole output
neurons…
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