grant
Quantification of Multi-Compartment T1 Relaxation and Magnetization Transfer in Biological Tissue: From Biophysics to Biomarkers for Multiple Sclerosis
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAD dementiaAI systemAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaArtificial IntelligenceAtrophicAtrophyAxonBiologicalBiological MarkersBiophysicsBody TissuesBrainBrain Nervous SystemBrain imagingCNS plasticityCell Communication and SignalingCell SignalingCharacteristicsChronicClinicalClinical TrialsCommunicationComplexComputer ReasoningDataDementiaDependenceDevelopmentDiseaseDisorderDisseminated SclerosisEncephalonEngineeringExhibitsFe elementFormulationGeneral RadiologyGliaGlial CellsGoalsHybridsHydrogen OxideIndividualInflammationIntracellular Communication and SignalingIronKnowledgeKolliker's reticulumLesionLiteratureLongitudinal StudiesMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMachine IntelligenceMagnetic Resonance ImagingMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodologyMethodsModelingMulti-center studiesMulticenter StudiesMultiple SclerosisMyelinNMR ImagingNMR TomographyNatureNerve DegenerationNeural DevelopmentNeurogliaNeuroglial CellsNeurologicNeurologicalNeuron DegenerationNeuronal PlasticityNon-neuronal cellNonneuronal cellNuclear Magnetic Resonance ImagingOrganOutcomeParameter EstimationPathologyPhysicsPhysiologic pulsePlayPrimary Senile Degenerative DementiaProcessPulseRadiologyRadiology SpecialtyReference RangesReference ValuesRelapseRelaxationReportingReproducibilityResearchResolutionRoleRotationSamplingScanningSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingSolidSpecificityTestingTherapeuticTimeTissuesTrainingVariantVariationWaterWorkZeugmatographyagesassess effectivenessbio-markersbiologicbiologic markerbiological signal transductionbiomarkerbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical modelbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbrain tissuebrain visualizationcentral nervous system plasticityclinical imagingclinical outcome measurescomparativedesigndesigningdetermine effectivenessdevelopmentaldisabilityeffectiveness assessmenteffectiveness evaluationevaluate effectivenessexamine effectivenessgray matterimage constructionimage generationimage reconstructionimaging in vivoimprovedin vivoin vivo imaginginsular sclerosislong-term studylongitudinal outcome studiesmagnetic resonance imaging biomarkermagnetic resonance imaging markermagnetic transfer imagingmagnetization transfer imagingnerve cementneural degenerationneural imagingneural plasticityneuro-imagingneurodegenerationneurodegenerativeneurodevelopmentneuroimagingneurological degenerationneurological imagingneuronal degenerationneuroplasticneuroplasticityprecision medicineprecision-based medicineprimary degenerative dementiaradiologistresolutionsroutine imagingsenile dementia of the Alzheimer typesocial rolesubstantia albasubstantia griseathree dimensionaltoolwhite matter
Description preview
Project Summary
The overarching goal of this project is to improve the reproducibility of quantitative MRI (qMRI).
Secondary goals are to enhance its sensitivity and specificity, and to enable its utilization in clinical
routine imaging by reducing the scan time. Successful completion of this project will help towards the
fulfillment of qMRI's…
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