grant
Purinergic Signaling in Fibroblast Activation and Lung Fibrosis
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ADP PhosphohydrolaseADPaseATP DiphosphohydrolaseATP HydrolysisATP ReceptorsATP-ADPaseATP-DiphosphataseActive OxygenAcuteAddressAdenosine DiphosphataseAirway failureAnimal ModelAnimal Models and Related StudiesApyraseB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BleoBleomycinBody TissuesBone-Derived Transforming Growth FactorBronchioalveolar LavageBronchoalveolar LavageBronchoalveolar Lavage FluidBronchopulmonary LavageCSAID-Binding Protein 1CSAID-Binding Protein 2CSBP2Ca(2+)-Calmodulin Dependent Protein KinaseCaM KIICaM PK IICaM kinase IICaMKCaMKIICalciumCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCalcium/calmodulin-dependent protein kinaseCalmodulin-Dependent Protein KinasesCalmodulin-KinaseCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellular ProliferationCessation of lifeChemicalsChronicClosure by LigationCollagenCollagen GeneCytokine-Suppressive Antiinflammatory Drug-Binding Protein 1Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2DataDeathDepositDepositionDevelopmentDiseaseDisease ProgressionDisorderDoseDysfunctionEnzyme GeneEnzymesFibroblastsFibrosing AlveolitisFibrosisFunctional disorderGenerationsGoalsHPGFHepatocyte-Stimulating FactorHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinImageIn VitroIn-bleomycinInflammatoryInjuryInterleukin-6Intracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeLigationLinkLungLung DiseasesLung InflammationLung LavageLung Respiratory SystemLung Tissue FibrosisMAP Kinase Signaling PathwaysMAPK14MAPK14 Mitogen-Activated Protein KinaseMAPK14 geneMAPKinase Signaling PathwayMGI-2MeasuresMediatingMediatorMiceMice MammalsMilk Growth FactorMitochondriaMitogen-Activated Protein Kinase 14ModelingModern ManMolecularMurineMusMxi2Myeloid Differentiation-Inducing ProteinNatureNull MouseOfevOxygen RadicalsPathogenesisPathologicPathologyPathway interactionsPatientsPhenotypePhysiopathologyPlasmacytoma Growth FactorPlatelet Transforming Growth FactorPneumonitisPro-OxidantsProcessProductionProliferatingPulmonary DiseasesPulmonary DisorderPulmonary FibrosisPulmonary InflammationPurine ReceptorsPurinergic ReceptorsPurinoceptorReactive Oxygen SpeciesReporterReportingResearchRespiratory FailureRoleSAPK2AShort interfering RNASignal InductionSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSliceSmall Interfering RNAStress-Activated Protein Kinase 2ASuperoxide AnionSuperoxide RadicalSuperoxidesTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticTherapeutic InterventionTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneUpregulationVDCCVentilator-induced lung injuryVoltage-Dependent Calcium Channelsbiological signal transductionbronchiolar alveolar lavagebronchopulmonary lavage therapycalcium-calmodulin-dependent PKcalcium-calmodulin-dependent PK type IIcalcium-dependent CaM kinase IIcalmodulin dependent protein kinasecalmodulin-dependent protein kinase IIclinical developmentclinical relevanceclinically relevantcurative interventioncurative therapeuticcurative therapycurative treatmentscytokinedetermine efficacydevelopmentaldiffuse interstitial pulmonary fibrosisdisease of the lungdisorder of the lungeffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperimentexperimental researchexperimental studyexperimentsextracellularfibrogenesisfibrosis in the lungfibrotic lung diseasefibrotic pulmonary diseasehuman modelidiopathic pulmonary fibrosisimagingin vivoindium-bleomycininhibitorinjuriesinsightinterferon beta 2intervention therapyknock-downknockdownlung disorderlung fibrosismicrotubule associated protein 2 kinasemitochondrialmodel of animalmodel of humanmouse modelmurine modelnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnintedanibnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetp38p38 MAP Kinasep38 MAPK Genep38 Mitogen Activated Protein Kinasep38 Protein Kinasep38 SAPKp38-Alphap38Alphapathogen exposurepathophysiologypathwayprofibrotic fibroblastprotein kinase IIresponsescRNA sequencingscRNA-seqsiRNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestandard of caretargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentuptakeventilation induced lung injuryventilator associated lung injury
Description preview
Project Summary/Abstract
Idiopathic pulmonary fibrosis (IPF) is a devastating and progressive lung disease characterized by extensive
fibrotic remodeling leading to respiratory failure and death. Despite recent advancements, no curative treatments
exist for IPF, underscoring the urgent need to identify novel therapeutic targets. Recent studies…
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