grant
PTM-driven mechanisms of cell signaling
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025APF-1ATP-Dependent Proteolysis Factor 1AddressAllelesAllelomorphsAutophagocytosisBindingBiochemicalBiochemistryBiological ChemistryBiologyC-terminalCD38-Negative KinaseCRISPRCRISPR/Cas systemCell BodyCell Communication and SignalingCell SignalingCellsClinicalClinical PathsClinical PathwaysClustered Regularly Interspaced Short Palindromic RepeatsComplexDNA Molecular BiologyDNA Sequence RearrangementDarknessDataDiseaseDisorderEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEncapsulatedEngineeringEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorFundingGoalsHMG-20HealthHigh Mobility Protein 20HumanIFNIn VitroInflammationInflammatoryInterferonsIntracellular Communication and SignalingJobsKinasesLinkLipidsMediatingModern ManMolecular BiologyMolecular InteractionNIGMSNational Institute of General Medical SciencesNon-Receptor Tyrosine Kinase 1Nonreceptor Tyrosine Kinase 1Nucleic AcidsNutrientOccupationsOncogenicPathologicPathway interactionsPhosphotransferase GenePhosphotransferasesPhysical condensationPolyubiquitinProfessional PositionsProtein Tyrosine KinaseProtein Tyrosine Kinase EEKPublic HealthRegulationResearchRoleSignal TransductionSignal Transduction SystemsSignalingSiteSystemTNK1TNK1 geneTransphosphorylasesTyrosine KinaseTyrosine Kinase, Nonreceptor, 1Tyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein KinaseUbiquitinWorkautophagybiological signal transductioncondensationdesigndesigningdrug developmentgenomic rearrangementhuman diseasehydroxyaryl protein kinaseinhibitorinsoluble aggregatemouse modelmurine modelnew approachesnovelnovel approachesnovel strategiesnovel strategypathwayphase 1 trialphase I trialpoly-ubiquitinprotein aggregateprotein aggregationrecruitsmall molecular inhibitorsmall molecule inhibitorsocial rolestructural biologytherapeutic targettyrosyl protein kinase
Description preview
PROJECT SUMMARY
This MIRA/R35 application is designed to replace our NIGMS R01 GM147310-01 and a recent NIGMS R01
application that was scored on first submission but rejected based on not being able to have two simultaneous
NIGMS R01s. Following NIGMS advice, I have consolidated these projects into this MIRA application. Our
overarching goal is to…
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