grant
PTEX mechanism in malaria parasite effector protein export and host cell subversion
NIHUS FederalResearch GrantFY2025Anti-malarialsBiologyBloodBlood Reticuloendothelial SystemBlood erythrocyteCell BodyCellsChaperoneComplexCryo-electron MicroscopyCryoelectron MicroscopyCuriositiesDataDevelopmentDiseaseDisorderDrug resistanceElectron CryomicroscopyErythrocytesErythrocyticEventGenetics-MutagenesisHepatic CellsHepatic Parenchymal CellHepatocyteHost DefenseInfectionLabelLicensingLife StyleLifestyleLinkLiverLiver CellsMalariaMarrow erythrocyteMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane TransportMembrane-Associated ProteinsMethodsModelingMolecular ChaperonesMutagenesisMutagenesis Molecular BiologyN-terminalNH2-terminalNutrientPaludismParasitesParasitic DiseasesPathogenesisPathogenicityPathologicPathway interactionsPermeabilityPlasmodiumPlasmodium InfectionsPlasmodium aspartic proteinase GProcessProtein ExportProtein Export PathwayProteinsPublic HealthRed Blood CellsRed CellRegulationResistanceRoleSecureSiteStructureSurface ProteinsSystemTestingTimeTransmembrane TransportVacuoleanti-malarial agentsanti-malarial drugsaspartic hemoglobinaseaspartic hemoglobinase Iblood corpusclescombatconditional mutantconditional mutationcrosslinkcryo-EMcryoEMcryogenic electron microscopydevelopmentaldrug resistantfitnesshepatic body systemhepatic organ systemin vivointrahepaticknock-downknockdownliver infectionmembrane structurenew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnon-natural amino acidsnon-proteinogenic amino acidsnonproteinogenic amino acidsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetobligate intracellular parasitepathogenpathwayplasmepsinplasmepsin Iplasmepsin proteaseprotein complexprotein functionresistance to Drugresistantresistant to Drugsocial roleunfoldaseunnatural amino acids
Description preview
Project Summary
Malaria disease remains a serious public health problem. Progress in Malaria control has slowed
in recent years while resistance to frontline antimalarials is emerging in the most afflicted regions,
underscoring a pressing need for deciphering fundamental parasite biology to provide novel
therapeutic strategies. This obligate…
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