grant
PROVIDENT: Prepositioning Optimized Strategies for Vaccines and Immunotherapeutics against Diverse Emerging Infectious Threats
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Ab-mediated immunityAb-mediated protectionAcademiaAchievementAchievement AttainmentAdvanced DevelopmentAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody RepertoireAntibody ResponseAntibody immunityAntibody protectionAntibody-mediated protectionAntigensAssayBioassayBiologicalBiological AssayBispecific Monoclonal AntibodiesBlood VesselsBunyavirusCell BodyCell Surface AntigensCellsCellular ImmunologyCollaborationsComplementComplement ProteinsCritical PathsCritical PathwaysData Management CoreDevelopmentDiseaseDisease OutbreaksDisorderDissectionDoseEngineeringEvaluationEventExerciseFamilyFutureGeneticGenotypeGlycoproteinsGoalsGovernmentHantavirusHost FactorHost Factor ProteinHumanImmune responseImmunizeImmunochemical ImmunologicImmunologicImmunologicalImmunological Surface MarkersImmunologicallyImmunologicsImmunotherapeutic agentIndustryInfectionInstitutionIntegration Host FactorsKnowledgeLeadMapsMiningModern ManMolecularNairovirusNon-Polyadenylated RNAOrthobunyavirusOrthohantavirusesOrthonairovirusOutbreaksParamyxoviridaeParamyxovirusPathogenesisPathogenicityPathway interactionsPb elementPhasePlayPositionPositioning AttributeProteinsProteomicsR-Series Research ProjectsR01 MechanismR01 ProgramRNARNA Gene ProductsRNA VirusesRNA vaccineRNA-based vaccineReceptor ProteinRecombinantsRegulatory approvalResearchResearch GrantsResearch Project GrantsResearch ProjectsRibonucleic AcidRisk AssessmentSafetySeriesSerotypingStructureSurface AntigensT cell responseTestingTherapeuticTherapeutic UsesTherapeutic antibodiesToxinTransgenic AnimalsVaccinationVaccine DesignVaccinesValidationViralViral DiseasesViral PathogenesisVirusVirus Diseasesantibody-mediated immunitybi-specific monoclonal antibodiesbiologicclinical translationclinically translatablecommercializationcomplementationdata management and coordinating centerdata management centerdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalendothelial dysfunctionepidemic concernepidemic potentialepidemic riskepidemic threatexperimentexperimental researchexperimental studyexperimentsheavy metal Pbheavy metal leadhost responseimmune drugsimmune system responseimmune-based therapeuticsimmunogenimmunogenicityimmunologic therapeuticsimmunoresponseimmunotherapeuticsimmunotherapy agentin vivoindustrial partnershipindustry partnerindustry partnershipmRNA vaccinemRNA-based vaccinemembermodel of animalnon-human primatenonhuman primatepandemic concernpandemic potentialpandemic riskpandemic threatpathwayprophylacticprotective efficacyprototypereceptorregulatory authorizationregulatory certificationregulatory clearanceresponserisk mitigationsafety assessmentstructural biologytoolvaccine antibodiesvaccine developmentvaccine induced antibodiesvaccine platformvaccine strategyvaccine-induced antibodiesvalidationsvascularviral infectionviral infection mechanismvirologyvirus host interactionvirus infectionvirus infection mechanismvirus pathogenesisvirus-induced disease
Description preview
The overarching goal of PROVIDENT (Prepositioning Optimized Strategies for Vaccines and Immunotherapeu-
tics against Diverse Emerging Infectious Threats) is to deliver “plug-and-play” vaccine and therapeutic an-
tibody blueprints for emerging enveloped RNA viruses belonging to three families—Nairoviridae, Han-
taviridae, and Paramyxoviridae.…
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