grant
Proteomic and metabolomic trajectories of ARDS molecular phenotypes
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 20 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY202521+ years oldARDSAcute Respiratory DistressAcute Respiratory Distress SyndromeAdmissionAdmission activityAdultAdult ARDSAdult HumanAdult RDSAdult Respiratory Distress SyndromeAirway failureAlveolarAutomobile DrivingBioinformaticsBiologicalBiological MarkersBiometricsBiometryBiostatisticsBlood PlasmaCaliforniaCell BodyCellsCharacteristicsClinicalCohort StudiesCompetenceComputing MethodologiesConcurrent StudiesCritical CareCritical IllnessCritically IllDa Nang LungDataData AnalysesData AnalysisDeath RateDiagnosisDrug TargetingDrug TherapyEnrollmentEpidemiologic MethodologyEpidemiologic MethodsEpidemiologic research methodologyEpidemiologic research methodsEpidemiological MethodsEpidemiological TechniquesEvolutionGenomeGenomicsGoalsHospitalsIndividualIndividual DifferencesInduction of neuromuscular blockadeInflammationInflammation MediatorsInflammatoryInjuryIntensive Care UnitsInvestigatorsK23 AwardK23 MechanismK23 ProgramKineticsLipidsLower respiratory tract structureLungLung DiseasesLung Respiratory SystemLung damageMeasuresMechanical ventilationMediatingMediatorMedicineMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMetabolicMethodologyMethods EpidemiologyMethods in epidemiologyMitochondriaMolecularNHLBINamesNational Heart, Lung, and Blood InstituteNeuromuscular BlockNeuromuscular BlockadeObservation researchObservation studyObservational StudyObservational researchOutcomePathogenesisPathway interactionsPatientsPersonsPharmacological TreatmentPharmacometabolomicsPharmacometabonomicsPharmacotherapyPhenotypePlasmaPlasma ProteinsPlasma SerumProspective, cohort studyProteinsProteomicsPublic HealthPublishingPulmonary DiseasesPulmonary DisorderRandomized, Controlled TrialsRecoveryResearchResearch PersonnelResearch SpecimenResearchersResolutionRespiratory FailureReticuloendothelial System, Serum, PlasmaSamplingSan FranciscoSepsis and ARDSShock LungSiteSpecimenStatistical MethodsStiff lungSurvivorsSystems BiologyTestingTimeTracheaTrachea ProperTrainingTranslational ResearchTranslational ScienceUniversitiesValidationWorkacute respiratory distress syndrome caused by sepsisadulthoodaspiratebio-markersbiologicbiologic markerbiological heterogeneitybiomarkercareer developmentcohortcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddata interpretationdisease of the lungdisorder of the lungdrivingdrug interventiondrug treatmenteffective therapyeffective treatmentenrollimprovedinflammatory mediatorinjuriesinsightinstructorlipid mediatorlower respiratory tractlung disorderlung injurymechanical respiratory assistmechanically ventilatedmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmitochondrialmolecular phenotypemortalitymortality ratemortality ratiomulti-modalitymultimodalitynamenamednamingobservational cohort studyoutcome predictionparticipant enrollmentpathwaypatient centeredpatient enrollmentpatient orientedpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprecision medicineprecision-based medicineprospectiveprotein biomarkersprotein markerspulmonarypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrandomized control trialresolutionsrespiratoryresponse to therapyresponse to treatmentrestorationsecondary analysissepsis ARDSsepsis acute respiratory distress syndromesepsis and acute respiratory distress syndromesepsis associated acute respiratory distress syndromesepsis induced ARDSsepsis induced acute respiratory distress syndromesepsis related acute respiratory distress syndromeskillsstatistic methodssystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapeutic targettherapy responsetranslation researchtranslational investigationtreatment responsetreatment responsivenessvalidationswet lungwindpipe
Description preview
ABSTRACT. This application is for a K23 award for Narges Alipanah-Lechner, MD, MAS, a Clinical Instructor
in the Division of Pulmonary/Critical Care Medicine at the University of California San Francisco. Dr. Alipanah-
Lechner is a young investigator in patient-oriented translational research in the acute respiratory distress
syndrome (ARDS). This…
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