grant
Protein quality control at eukaryotic membranes
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 15 Aug 2018Deadline 31 May 2029
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAddressAntigen-Antibody ComplexAssayBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryCell BodyCellsCellular StressCellular Stress ResponseCellular biologyCytosolDataDislocationsER stressEndoplasmic ReticulumErgastoplasmGeneticGoalsImmune ComplexIntegral Membrane ProteinIntrinsic Membrane ProteinMacropainMacroxyproteinaseMechanicsMedicalMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMulticatalytic ProteinaseOrganellesPathway interactionsPhysiologicPhysiologicalProcessProsomeProteasomeProteasome Endopeptidase ComplexProteinsProteosomeQuality ControlSurface ProteinsSystemTransmembrane ProteinTransmembrane Protein GeneWorkaberrant protein foldingabnormal protein foldingbacteria pathogenbacterial pathogencell biologycell stressdesigndesigningendoplasmic reticulum stressin vitro Assayin vivoinnovateinnovationinnovativemechanicmechanicalmembrane structuremulticatalytic endopeptidase complexpathogenpathogenic bacteriapathogenic viruspathologic protein foldingpathwayprotein misfoldingtherapeutic targetviral pathogenvirus pathogen
Description preview
Project Summary/Abstract
Integral membrane protein quality control systems are present within every major eukaryotic organelle. The
archetypal integral membrane protein quality control system is called Endoplasmic reticulum-associated
degradation (ERAD). For ERAD, ER proteins are degraded, either because they are misfolded or because their…
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