grant
Protein-nucleic acid interactions in basic cellular processes
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Sept 2019Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AreaBacteriophagesBiological FunctionBiological ProcessCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessComplexCryo-electron MicroscopyCryoelectron MicroscopyCyclicityDNADNA DamageDNA InjuryDNA PolymerasesDNA ReplicationDNA Restriction-Modification EnzymesDNA SynthesisDNA biosynthesisDNA lesionDNA-Dependent DNA PolymerasesDNA-Directed DNA PolymeraseDefense MechanismsDeoxyribonucleic AcidElectron CryomicroscopyEukaryotaEukaryoteEukaryotic CellGenotoxic StressImmunityInfectionIntracellular Communication and SignalingInvadedNucleic AcidsOligoOligonucleotidesPeriodicityPhagesPolymerasePopulationProkaryotaeProkaryotic CellsProteinsResearchRestriction-Modification SystemsRhythmicityRoleSignal TransductionSignal Transduction SystemsSignalingStructureSubcellular ProcessSystemWorkbacterial virusbiological signal transductioncopingcryo-EMcryoEMcryogenic electron microscopygenome integritygenomic integrityoligospreventpreventingprokaryotepsychological defense mechanismsocial rolesuccess
Description preview
Abstract
Protein-nucleic acid interactions are central to many biological processes. Our research is
focused on two areas of protein-nucleic acid interactions: bacterial defense systems and
translesion DNA synthesis (TLS). The studies on bacterial defense systems are an extension of
our decades-long work on restriction-modification (R-M) systems.…
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