grant
Protein co-pathologies in Alzheimer's Disease and Related Dementias
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20265-HT5-Hydroxytryptamine5HTAD and related dementiaAD dementiaAD related dementiaADRDAcetylcholineAddressAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnteriorAutopsyAβBiological MarkersBiopsyBrainBrain Nervous SystemBrain PathologyBrain StemBrain regionBrainstemCaringCell BodyCell DeathCell NucleusCellsCellular MorphologyClassificationClinicalCognitionCognitive deficitsComplexCutaneousDLG4DLG4 geneDataDementiaDendritesDermatologic biopsyDiagnosisDiseaseDisorderDistalDorsalDrug TherapyEconomicsEncephalonEnteramineEvaluationFTD dementiaFrontal Temporal DementiaFrontotemporal DementiaGoalsGolgiGolgi ApparatusGolgi ComplexHigh Throughput AssayHippophaineHumanHuman ResourcesImmunofluorescenceImmunofluorescence ImmunologicIndividualLB dementiaLevarterenolLevonorepinephrineLewy Body DementiaLewy Body Type Senile DementiaLewy dementiaLocationLocus CoeruleusMT-bound tauManpowerMapsMethodsMicrotomyModelingModern ManMorphologyNAC precursorNerveNerve CellsNerve DegenerationNerve UnitNeural CellNeuritesNeuritic PlaquesNeurocyteNeurofibrillary TanglesNeuron DegenerationNeuronsNoradrenalineNorepinephrineNucleusNucleus Pigmentosus PontisOutcomePARK1 proteinPARK4 proteinPSD95Paralysis AgitansParkinsonParkinson DiseasePathologyPatientsPatternPeripheralPeripheral NervesPharmacological TreatmentPharmacotherapyPopulationPrevalencePrimary ParkinsonismPrimary Senile Degenerative DementiaProteinsPyramidal neuronReproducibilityResearchRisk FactorsRoleSAP90SNCASNCA proteinSamplingSenile PlaquesSerotoninSkinSpinal ColumnSpineStaining methodStainsSymptomsSynapsesSynapticSynaptic Vesicle P38 Membrane ProteinSynaptic Vesicle Protein P38SynaptophysinSystematicsTAR DNA-binding protein 43TDP-43TDP43TechniquesTestingThin SectioningVertebral columna beta peptidea-syna-synucleinabetaage associatedage correlatedage dependentage linkedage relatedage specificalpha synucleinalpha synuclein genealphaSP22amyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinasynaβ plaquesbackbonebeta amyloid fibrilbio-markersbiologic markerbiomarkerblue nucleuscell morphologycell typecholinergicclinical diagnosiscognitive defectscored plaquecostcutaneous biopsydensitydiffuse plaquedrug interventiondrug treatmentearly onseteconomicfront temporal dementiafrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiahigh definitionhigh throughput screeninghigh-resolutionhippocampal pyramidal neuroninsoluble aggregatelocus ceruleus structuremicrotubule bound taumicrotubule-bound taunecrocytosisnecropsyneural degenerationneurodegenerationneurodegenerativeneurodegenerative dementianeurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurological degenerationneuronalneuronal degenerationnew markernon A-beta component of AD amyloidnon A4 component of amyloid precursornoradrenergicnovel biomarkernovel markerp-taup-τpersonnelpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphospho-tauphospho-τphosphorylated taupost-translational modification of taupostmortempostsynapticposttranslational modification of taupresynapticprimary degenerative dementiaprotein TDP-43protein TDP43protein aggregateprotein aggregationresponserisk sharingsenile dementia of the Alzheimer typeskin biopsysocialsocial rolesoluble amyloid precursor proteinsynapsesynucleinopathytangletautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1α synuclein geneα-synα-synucleinτ Proteinsτ phosphorylation
Description preview
Abstract
Dementia is associated with staggering economic, social, and personnel costs. Strikingly, most dementia
cases have co-pathologies beyond the dominant type. Research suggests these non-dominant protein
aggregates can impact cognition, symptoms, and progression. These findings motivate our central hypothesis
that individual pathologies…
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