grant
Protection Against Nosocomial Infections After Severe Burn Injury Through Trained Immunity
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 May 2021Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY2026AddressAgonistAwardBiogenesisBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood leukocyteBlood monocyteBurn injuryBurnsCell BodyCell EnergeticsCellsCellular Immune FunctionDangerousnessDevelopmentDysfunctionEnsureFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2Functional disorderGlycolysisHospital InfectionsHospital acquired infectionHumanImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune MarkersImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune mediated therapyImmune systemImmunesImmunityImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologic DiseasesImmunologic MarkersImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologically Directed TherapyImmunosuppressed HostImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyImpairmentIndividualInfectionIntermediary MetabolismK pneumoniaeK. pneumoniaeKlebsiella pneumoniaeLeukocytesLeukocytes Reticuloendothelial SystemLifeLipid AMacrophageMarrow NeutrophilMarrow leukocyteMarrow monocyteMechanistic Target of RapamycinMediatingMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMethodologyMiceMice MammalsMitochondriaModelingModern ManMolecularMorbidityMurineMusMyeloid CellsMφNeutrophilic GranulocyteNeutrophilic LeukocyteNosocomial InfectionsOrigin of LifeP aeruginosaP. aeruginosaPBMCPathway interactionsPatientsPeripheral Blood Mononuclear CellPhysiopathologyPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPseudomonas aeruginosaPseudomonas pyocyaneaRAFT1RecoveryResearchResistance to infectionS aureusS. aureusSamplingStaph aureusStaphylococcus aureusTLR proteinTherapeuticToll-Like Receptor Family GeneToll-like receptorsTrainingTranslational InhibitionTranslational RepressionWhite Blood CellsWhite CellWorkanti-microbialantimicrobialburn modelburnedclinical relevanceclinically relevantdevelopmentalexhaustionfightingflexibilityflexiblefunctional outcomesimmune activationimmune functionimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based biomarkersimmune-based therapiesimmune-based treatmentsimmuno therapyimmunological biomarkersimmunological markersimmunosuppressed patientimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinfection resistanceinnovateinnovationinnovativeinstitutional infectionmTORmammalian target of rapamycinmitochondrialmonocytemortalityneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpathophysiologypathwayprogramsrecruitresponsescRNA sequencingscRNA-seqserious burnssevere burnssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingwhite blood cellwhite blood corpusclewound assessmentwound carewound monitoring
Description preview
PROJECT SUMMARY
Severe burn injuries result in immune and metabolic dysfunction, leaving patients vulnerable to life-threatening
infections, which remain a leading cause of morbidity and mortality. These vulnerabilities arise from immune
exhaustion, metabolic impairments, and disrupted leukocyte function, leading to prolonged
immunosuppression.…
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