grant
Promoting a reparative instead of a degenerative outcome from loading of fatigue-damaged tendons
NIHUS FederalResearch GrantFY2025AdhesionsApoptosisApoptosis PathwayAreaAutopsyBiologicalBone-Derived Transforming Growth FactorCD49e AntigensCell BodyCell DeathCell Growth in NumberCell MultiplicationCell ProliferationCell ProtectionCell SurvivalCell ViabilityCell-Extracellular MatrixCellsCellular MatrixCellular ProliferationChondroitin Sulfate BChronicClinicalClinical DataCollagenCollagen FiberCommon Rat StrainsCytoprotectionCytoskeletal SystemCytoskeletonDataDepositDepositionDermatan SulfateDiagnosticDisparateDuran-Reynals Permeability FactorECMEnvironmentExerciseExercise TherapyExtracellular MatrixFNRAFatigueFibronectin Receptor Alpha SubunitFluorescenceFoundationsGL EnzymeGaitGlycosaminoglycansHyaglosidaseHyaluronanHyaluronate 4-glycanohydrolaseHyaluronate HydrolaseHyaluronidaseHyaluronoglucosaminidaseITGA5ITGA5 geneInhibition of ApoptosisInjuryIntegrin Alpha 5Integrin alpha-5 beta-1Integrin alpha5Integrin alpha5beta1Integrin alphaFIntegrin α5Integrin α5β1IntegrinsIntegrins Extracellular MatrixInvestigationLacerationLack of EnergyLinkMechanicsMediatingMilk Growth FactorModerate ExerciseModulusMorphologyMucopolysaccharidesMyofibroblastOutcomePathogenesisPatientsPeptidesPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlatelet Glycoprotein IcPlatelet Glycoprotein Ic/IIaPlatelet Transforming Growth FactorPopulationPositionPositioning AttributeProcessProgrammed Cell DeathProliferatingPropertyProtocolProtocols documentationRatRats MammalsRattusRoleRunningRuptureSeveritiesSimvastatinStimulusStrenuous ExerciseSynvinolinTGF BTGF-betaTGF-βTGFbetaTGFβTendinitisTendinopathyTendon InjuriesTendon structureTendonitisTendonsTestingTherapeuticTherapeutic EffectTherapeutic exerciseTimeTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneVLA-5VLA-5 ReceptorsVLA-5 alpha ChainVLA5Aalpha(5) Integrinantagonismantagonistbeta-Heparinbiologiccell typechondroitinase Bcytoprotectiveexercise treatmentimprovedin vivoin vivo Modelinjuriesinjury of musculoskeletal system (disorder)injury of musculoskeleted systemintense exerciseintracellular skeletonmechanicmechanicalmechanical propertiesmoderate physical activitymusculoskeletal injurymusculoskeletal traumanecrocytosisnecropsynew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation diagnosticsnext generation therapeuticsnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypatellar tendonpharmaceuticalpostmortempreventpreventingrepairrepairedresponseresponse to therapyresponse to treatmentscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestrenuous activitystrenuous physical activitytendon rupturetherapeutic responsetherapeutic targettherapy responsetissue repairtreated with exercisetreatment responsetreatment responsivenessvigorous exercisevigorous physical activity
Description preview
Tendinopathies are common injuries that typically result from accumulation of sub-rupture fatigue damage. We
have developed an in vivo model of sub-rupture fatigue damage accumulation using the rat patellar tendon to
investigate the onset and pathogenesis of tendinopathy. We found that just one bout of fatigue loading results in
collagen matrix…
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