grant
Projection-specific mechanisms mediating postpartum stress effects on the maternal brain
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026AcuteAddressAdvisory CommitteesAffectAffective DisordersAmmon HornAnxietyAnxiety DisordersApplications GrantsBasal Transcription FactorBasal transcription factor genesBehaviorBehavioralBrainBrain Nervous SystemBrain regionCaringCell BodyCell Communication and SignalingCell SignalingCellsChemicalsChild CareChild RearingChromatinChronicChronic stressChronologic Fetal MaturityCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexCornu AmmonisCoupledDataDepressive SyndromesDepressive disorderDisturbance in cognitionDopamineDopamine ReceptorDorsalEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsExpression SignatureFeelingFemaleFetal AgeFutureGene ExpressionGene Expression ProfileGeneral Transcription Factor GeneGeneral Transcription FactorsGestationGestational AgeGrant ProposalsHippocampusHumanHydroxytyramineImpaired cognitionIndividualInfantIntervention StrategiesIntracellular Communication and SignalingLearningLong-Term EffectsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMaternal MortalityMediatingMemoryMental HealthMental HygieneMentorshipMiceMice MammalsModelingModern ManMolecularMood DisordersMothersMurineMusNational Institutes of HealthNerve CellsNerve UnitNeural CellNeurocyteNeuronsNulliparasNulliparityNulliparousOutcomeParentingParenting behaviorPerformancePerinatalPeripartumPhenotypePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPostpartum PeriodPosttranslational ModificationsPosttranslational Protein ProcessingPredispositionPregnancyPregnancy HistoriesProtein ModificationProteinsPsychological HealthPuericultureReceptor SignalingResearchRiskRisk FactorsRodentRodentiaRodents MammalsRoleSelf EfficacyShapesSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSocial supportStimulusStressSusceptibilitySystemTask ForcesTestingTimeTrainingTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceUnited States National Institutes of HealthVentral Tegmental AreaViral Vectoradvisory teamanxiety-like behaviorbehavioral plasticitybiological signal transductionbirth complicationsbrain healthcareercareer developmentcell typechildrearingcognitive dysfunctioncognitive lossdelivery complicationsdesigndesigningdisease riskdisorder riskepigenetic regulationepigeneticallyepigenomicsexperiencefeelingsgene expression patterngene expression signaturehippocampalinsightlife spanlifespanmaternal deathmaternal morbiditymouse modelmultiomicsmultiple omicsmurine modelneural imagingneuro-imagingneuroimagingneurological imagingneuronalnoveloffspringpanomicsparityperinatal periodperinatal phasepost-partumprogramsreproductiveresponsesNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesocial support networktranscription factortranscriptional profiletranscriptional signaturetranscriptomicsventral tegmentum♀
Description preview
Project Summary
Perinatal or Postpartum Mood and Anxiety Disorders (PMADs) are leading causes of maternal morbidity and
mortality, prompting great need to understand factors that influence risk. Parity, the state of having carried
pregnancies to a viable gestational age, can promote positive parenting adaptations and/or increase the risk of…
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