grant
Project IV
Organization UNIVERSITY OF MISSISSIPPI MED CTRLocation JACKSON, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AddressAdoptive TransferAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesArteriesAthymic RatsAutoantibodiesB blood cellsB cellB cell growth factorB cellsB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-CellsB-LymphocytesB-cellBCDF-1BCGFBCGF-1BCSF 1BP reductionBSF-1BSF1BinetrakinBlast TransformationBlastogenesisBlood PressureBlood VesselsCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCaproatesCell BodyCellsCells Placenta-TissueClinical ResearchClinical StudyClinical TrialsCommon Rat StrainsCorpus Luteum HormoneCytotoxic cellDataDelta4-pregnene-3,20-dioneDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderEDN1EPH GestosisET-1Endothelin Type 1Endothelin-1Experimental TherapiesFemaleFetal Body WeightFetal Growth RestrictionFetal Growth RetardationFetal MortalityFetal Mortality StatisticsFetal WeightFetusGamma-delta T cellsGestationGestational HypertensionHexanoatesHydroxyprogesteroneHypertensionHypertension induced by pregnancyIL-4IL4 ProteinIUGRImmuneImmunesInflammationInflammation MediatorsInflammatoryInterleukin-4Interleukin-4 PrecursorIntrauterine Growth RetardationInvestigational TherapiesInvestigational TreatmentsK lymphocyteKnowledgeLEF Transcription FactorLinkLymphoblast TransformationLymphocyte ActivationLymphocyte StimulationLymphocyte Stimulatory Factor 1Lymphocyte TransformationLymphoid Enhancer FactorMCGF-2Mast Cell Growth Factor-2Maternal MortalityMediatingMediatorMiscarriageMississippiModelingMorbidityMorbidity - disease rateNK CellsNK T cellNKT cellNatural Killer CellsNatural Killer T cellNormal PlacentomaNude RatsParticipantPatientsPhenotypePlacentaPlacenta Embryonic TissuePlacentomePlayPre-EclampsiaPreeclampsiaPregn-4-ene-3,20-dionePregnancyPregnancy Associated HypertensionPregnancy OutcomePregnancy ToxemiasPregnant WomenPregnenedionePremature LaborPremature Obstetric LaborPreterm LaborPrevalenceProgesteroneProgesterone ReceptorsProgestin ReceptorsProtein SecretionProteinsProteinuria-Edema-Hypertension GestosisRatRats MammalsRattusRecommendationRecurrenceRecurrentResearchResistanceRoleSex DifferencesSexual differencesSpontaneous abortionSupplementationT Cell FactorT-Cell Growth Factor 2T4 CellsT4 LymphocytesTCF Transcription FactorTestingTh-2 CellTh2 CellsTherapeutic ProgesteroneTimeType 2 Helper CellUterusVascular Hypertensive DiseaseVascular Hypertensive DisorderWomanautoimmune antibodyautoreactive antibodyblocking factorblood pressure reductioncytokinedevelopmentaleffective therapyeffective treatmentendothelial dysfunctionexpectant motherexpectant womenexpecting motherexpecting womenexperimental therapeutic agentsexperimental therapeuticsfemale treatmenthealthy pregnancyhigh blood pressurehyperpiesiahyperpiesishypertension during pregnancyhypertension in pregnancyhypertensive diseasehypertensive disorderhypertensive pregnancyimpaired fetal growthimprovedindexingindividuals who are pregnantinflammatory mediatorintra-uterine growth restrictionintra-uterine growth retardationintrauterine growth restrictionlower BPlower blood pressurelowers blood pressuremalematernal deathnatural killer T lymphocytenormotensivenoveloffspringpathophysiology of pre-eclampsiapathophysiology of preeclampsiapeople who are pregnantperinatal morbidityplacental transferpre-eclampticpregnancy characterized by hypertensionpregnancy disorderpregnancy hypertensionpregnancy toxemia/hypertensionpregnancy-related hypertensionpregnantpregnant femalespregnant motherspregnant peoplepregnant populationsprenatal growth disorderpreventpreventingreduce BPreduce blood pressurereduction in BPreduction in blood pressureresistantself reactive antibodysex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolethose who are pregnanttreat femalestreat womentreatment among femalestreatment among womentreatment in femalestreatment in womenvascularwombwomen who are pregnantwomen's treatmentγδ T cellsγδT cells♀♂
Description preview
Project Summary
Preeclampsia (PE) affects 5-7% of all pregnancies in the U.S. Despite being a leading cause of maternal death
and perinatal morbidity, the most widely accepted treatment is early delivery of the baby. Healthy pregnancy is
associated with elevations in progesterone and CD4+THelper 2 cells/uterine, NK (non-cytolytic) profile favoring…
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