grant
Project 3: Prevention and Treatment of Hearing and Vision Impairments for Reducing AD/ADRD risk
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 15 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD preventionAD related dementiaADRDActive Follow-upAddressAffectAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaBlindnessBody CompositionCaliforniaCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCataract ExtractionCausalityClinical TreatmentClinical TrialsCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalComplexDataData SetData SourcesDiminished VisionDisturbance in cognitionEpidemiologyEtiologyGene variantGeneticGenetic RiskGoalsHealthHealth and Retirement StudyHearingHearing AidsHearing LossHeart VascularHeterogeneityHypoacusesHypoacusisImpaired cognitionImpairmentIncidenceIndividualInequityInterventionIntervention TrialInterventional trialLinkLong-term cohort studyLongitudinal StudiesLongitudinal cohort studyLow VisionMeasurementMeasuresMendelian randomizationMethodsModernizationModificationNational Institutes of HealthNerve DegenerationNeuron DegenerationPartial SightPopulationPopulation Attributable RisksPopulation HeterogeneityPrevalencePreventionPrevention ResearchPrimary Senile Degenerative DementiaProcessPsychosocial FactorReduced VisionResearch DesignRisk FactorsRisk ReductionSample SizeSamplingSelection BiasSensorySensory impairmentSightSocio-economic statusSocioeconomic StatusSourceStudy TypeSubgroupSubnormal VisionTimeUncertaintyUnited States National Institutes of HealthVisionVisual impairmentWorkactive followupage associatedage correlatedage dependentage linkedage relatedage specificallelic variantalzheimer riskassistive hearing deviceassistive listening deviceattributable fractionbiobankbiorepositorycardiovascular riskcardiovascular risk factorcataract surgerycausationcirculatory systemclinical interventionclinical therapyco-morbidco-morbiditycognitive assessmentcognitive dysfunctioncognitive losscognitive testingcomorbiditydementia burdendementia riskdisease causationdisparity in healthdiverse populationsdoubtdysfunctional hearingepidemiologicepidemiologicalfollow upfollow-upfollowed upfollowupgenetic informationgenetic variantgenomic varianthealth disparityhearing amplificationhearing assistancehearing assistive devicehearing challengedhearing defecthearing deficienthearing deficithearing devicehearing difficultyhearing dysfunctionhearing impairmentheterogeneous populationhigh riskimprovedinnovateinnovationinnovativeinsightintegrated careintegrated health careintegrated model of carelarge scale datalarge scale data setslarge scale datasetslong-term studylongitudinal outcome studiesmalleable riskmodifiable riskmultiple data sourcesneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationolder adultolder adulthoodpopulation diversityprimary degenerative dementiaprogramspsychosocial variablesreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrisk factor for dementiarisk for dementiarisk-reducingsenile dementia of the Alzheimer typesexsex related variationsex variablesex variationsex-related variablesocialsocial health determinantssocio-economic positionsocioeconomic positionstudy designtreatment effecttrendtrial regimentrial treatmentvaries by sexvision impairmentvision lossvisual functionvisual lossvisually impaired
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REVISED PROJECT SUMMARY/ABSTRACT
Sensory impairments, including hearing and vision loss, affect up to 40% of older adults and have been linked to higher risk of Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD). Identification and treatment (or corrections) of hearing and vision impairment could be a high-impact strategy for…
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