grant
Project 3: Defining the biologic role and therapeutic implications of lncRNA in multiple myeloma
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 1 Dec 2011Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAreaAutomobile DrivingBM Stem CellBM derived progenitorBM progenitorBM- derived Stem CellsBackBasal Transcription FactorBasal transcription factor genesBehaviorBiologic ModelsBiologicalBiological ModelsBone MarrowBone Marrow Reticuloendothelial SystemBone Marrow Stem CellBone Marrow progenitorCRISPRCRISPR/Cas systemCell BodyCell CommunicationCell InteractionCell LineCell SurvivalCell ViabilityCell-to-Cell InteractionCellLineCellsCellular ExpansionCellular GrowthChromatinClassificationClinicalClinical TrialsClustered Regularly Interspaced Short Palindromic RepeatsCombined Modality TherapyComplexDF/HCCDNA-Protein InteractionDana-Farber Cancer InstituteDataData SetDependenceDevelopmentDiseaseDisorderDorsumDrug resistanceEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFrequenciesFunctional RNAFundingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGenomicsHumanHuman GenomeIn VitroLeftMediatingMetabolicModel SystemModelingModern ManMolecularMolecular TargetMultimodal TherapyMultimodal TreatmentMultiple MyelomaNon-Polyadenylated RNANoncoding RNANontranslated RNAOligoOligonucleotidesOutcomePathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPlasma-Cell MyelomaPlayProbabilityProcessProliferatingProteinsRNARNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqReportingResearchRibonucleic AcidRibonucleoproteinsRiskRisk MarkerRoleSpan 80SpecificityStrains Cell LinesSystematicsTechniquesTherapeuticTherapeutic AgentsTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTranslationsTumor CellUntranslated RNAValidationadipogenesisbench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebiologicbone marrow derived progenitorbone marrow derived stem cellsbone marrow stromal cellbone marrow stromal stem cellc mycc-myc Genescancer genomicscell growthclinical applicabilityclinical applicationcmyccombination therapycombined modality treatmentcombined treatmentcultured cell linedevelopmentaldifferential expressiondifferentially expresseddrivingdrug resistantepigeneticallyepigenomicsflexibilityflexiblegain of functiongene regulatory networkhuman whole genomeimprovedin vivoin vivo Modelinhibitorlipid biosynthesislipogenesisloss of functionmodel of animalmulti-modal therapymulti-modal treatmentmyelomamyelomatosisneoplastic cellnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnoncodingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoligosoncogenomicsoutcome predictionpathwaypatient oriented outcomespre-clinicalpreclinicalpredict clinical outcomeprognostic significanceprotein Bresistance to Drugresistant to Drugresponserisk predictorrisk predictorsscaffoldscaffoldingsmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial roletargeted agenttherapeutic targettranscription factortranscriptional differencestranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslationtranslational therapeuticstranslational therapyv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homologvalidations
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Project Summary – Project 3 Dana-Farber Cancer Institute
Our longstanding focus has been to understand the multiple myeloma (MM)-bone marrow stromal cell
interaction. We have utilized integrated genomic and epigenomic analysis and our in vitro and in vivo models of
MM cell in the bone marrow (BM) milieu to identify molecular targets and…
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