grant
Project 3
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 20 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20250-11 years old21+ years old3-D3-Dimensional3DAI systemAbnormal gaitAdolescentAdolescent YouthAdultAdult HumanAffectAgeAge YearsAlgorithmsAnatomic AbnormalityAnatomical AbnormalityAnkleApoplexyArtificial IntelligenceAxonBig DataBigDataBrain Vascular AccidentBurn injuryBurnsCOBRECell Communication and SignalingCell SignalingCenter of Biomedical Research ExcellenceCenters of Research ExcellenceCerebral PalsyCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCharcot Marie DisorderCharcot Marie Muscular AtrophyCharcot Marie Tooth DisorderCharcot Marie Tooth muscular atrophyCharcot-Marie DiseaseCharcot-Marie-ToothCharcot-Marie-Tooth DiseaseCharcot-Marie-Tooth neuropathyChildChild YouthChildren (0-21)ClinicalClinical ResearchClinical StudyClinical TrialsCommunitiesComputer ReasoningConsumptionContractureCoxaDataData CollectionDeformityDigital biomarkerDimensionsDisablingDiseaseDisease ProgressionDisorderDominantly-Inherited Spinocerebellar AtaxiasDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDyskinesia SyndromesEconomicsEnvironmentEquilibriumErb syndromeErb-Charcot syndromeEvaluationExhibitsFemaleFoot DeformitiesFutureGaitGait AnalysisGait abnormalityGait disorderGait disturbancesGait dysfunctionGait impairmentGeneticGenetic DiversityGenetic VariationGoalsGrainHMSN Type VHereditaryHereditary Motor-Sensory Neuropathy with Pyramidal SignsHereditary Spastic ParaplegiaHipHip region structureHomeIndividualInheritedInherited NeuropathyInternationalIntracellular Communication and SignalingKneeLengthLifeLower ExtremityLower LimbMachine IntelligenceMachine LearningMeasuresMembrum inferiusMonitorMotorMovement Disorder SyndromesMovement DisordersMulti-Institutional Clinical TrialMulti-center clinical trialMulti-center trialMulti-site clinical trialMulticenter TrialsMulticenter clinical trialMultisite clinical trialNatural HistoryNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNeuropathyOrphan DiseaseOutcome MeasureParalysis AgitansParkinsonParkinson DiseasePatientsPatternPeroneal Muscular AtrophyPhenotypePhysical FunctionPhysical activityPrimary ParkinsonismR-Series Research ProjectsR01 MechanismR01 ProgramRare DiseasesRare DisorderReference RangesReference ValuesRegio tarsalisResearch GrantsResearch Project GrantsResearch ProjectsReview LiteratureSchoolsSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSpastic ParaplegiaSpastic Paraplegia-Hypertrophic Motor-Sensory NeuropathySpecificitySpinocerebellar AtaxiasSpinocerebellar AtrophiesStratificationStrokeSystemTestingTherapeutic EffectTimeToesType V Hereditary Motor and Sensory NeuropathyValidationWalkingWalking impairmentWidthWorkactigraphactigraphyadulthoodagedagesbalancebalance functionbiological signal transductionbody sensorbody worn sensorbrain attackburnedcerebral vascular accidentcerebrovascular accidentclinical outcome measuresclinical trial readinesscrouch gaitdesigndesigningdigitaldigital markerdigital phenotypingdisabilitydisease severityearly phase trialeconomiceffectiveness trialexperiencegait examinationhealth related quality of lifehereditary neuropathyhomesimprovedjuvenilejuvenile humankidslife spanlifespanmachine based learningmalemeasurable outcomemetermotor impairmentmovement impairmentmovement limitationmultidisciplinaryneurogeneticsneurological diseaseneuropathicnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachorphan disorderoutcome measurementparalysis spinalis spasticaparaplegia spasticarecruitsensorsexspastic spinal paralysisspasticitystrokedstrokessystematic reviewthree dimensionalvalidationswalking pacewalking speedwearablewearable biosensorwearable devicewearable electronicswearable sensorwearable sensor technologywearable systemwearable technologywearable toolwearablesyoungster♀♂
Description preview
ABSTRACT/SUMMARY:
Hereditary spastic paraplegias (HSPs) are a diverse group of over 80 rare neurogenetic disorders, representing
the most common cause of inherited spasticity and related disabilities worldwide. All HSPs are characterized by
progressive lower limb spasticity, weakness, and significant motor impairment. Clinical Research Project 3…
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