grant
Project 3 Cerchietti
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 12 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AccountingAffectAgeAgingArchitectureAssayAttenuatedAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioassayBiologicalBiological AssayBiologyBody TissuesCancer GenesCancer-Promoting GeneCancersCell BodyCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellsCharacteristicsChromatinComplexDLBCLDNA MethylationDNA ModificationDNA Modification ProcessDNA mutationDataDevelopmentDiagnosisDiffuse Large B-Cell LymphomaDiseaseDisorderDoseECMElderlyEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventExtracellular MatrixFibroblastsGene ExpressionGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGerminal CenterGerminoblastic SarcomaGerminoblastomaGrowthHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHematopoieticHistonesHost FactorHost Factor ProteinImmuneImmune infiltratesImmune signalingImmunesImmuno-ChemotherapyImmunochemical ImmunologicImmunochemotherapyImmunoglobulin Enhancer-Binding ProteinImmunologicImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIn VitroInducer CellsInducer T-LymphocytesInflammagingInflammatoryInflammatory InfiltrateIntegration Host FactorsIntracellular Communication and SignalingIntrinsic factorLymphomaLymphoma cellLymphomagenesisMalignantMalignant - descriptorMalignant LymphomaMalignant NeoplasmsMalignant TumorMiceMice MammalsModelingMolecularMurineMusMutationNF-kBNF-kappa BNF-kappaBNFKBNuclear Factor kappa BNuclear Transcription Factor NF-kBOlder PopulationOncogenesOncogenesisOncogenicOutcomePathologicPathologyPathway interactionsPatientsPatternPersonsPhenotypePhysiologicPhysiologicalPhysiologyPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPredispositionProcessPrognosisProliferatingProtein ModificationReactionRegimenResistanceReticulolymphosarcomaRoleSignal TransductionSignal Transduction SystemsSignalingSoilStimulusStromal CellsStructure of germinal center of lymph nodeSubgroupSusceptibilitySystemT-CellsT-LymphocyteTestingTherapeuticTissue GrowthTissuesToxic effectToxicitiesTranscription AlterationTranscription Factor NF-kBTransforming GenesTreatment-related toxicityWorkactivated B cell likeactivated B cell typeadvanced ageage associatedage correlatedage dependentage linkedage relatedage specificage-related inflammationagedaged miceaged mouseagesaging associated inflammationattenuateattenuatesbiologicbiological signal transductioncell communitycellular communitychemo-immuno therapychemoimmunotherapychemotherapyclinical relevanceclinically relevantcohortcombinatorialcomparativecustomized therapycustomized treatmentdesigndesigningdevelopmentaldrivingelderly miceelderly patientepigeneticallygenome mutationgeriatrichealthy aginghealthy human aginghemopoieticimmune cell infiltrateimmune microenvironmentimmune suppressionimmune suppressive activityimmune suppressive functionimmunological synapseimmunosuppressive activityimmunosuppressive functionimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentimprovedin vivoindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinflamm-ageinginflamm-aginginflammation associated with agingkappa B Enhancer Binding Proteinlarge cell Diffuse non-Hodgkin's lymphomamalignancyneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnuclear factor kappa betaold miceolder groupsolder individualsolder patientolder personontogenypathwaypatient specific therapiespatient specific treatmentpermissivenesspharmacologicpre-clinicalpreclinicalprogramspromoterpromotorrational designresistantresponsesenior citizensocial roletailored medical treatmenttailored therapytailored treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapeutic toxicitytherapy associated toxicitytherapy related toxicitytherapy toxicitythymus derived lymphocytetreatment toxicitytreatment-associated toxicitytumor immune microenvironmenttumor-immune system interactionstumorigenesisunique treatment
Description preview
PROJECT 3: SUMMARY/ABSTRACT
This project focus in the biology of diffuse large B-cell lymphoma (DLBCL) in older individuals (i.e., patients 75
years or older). Based on findings in national cohorts from our group and others, DLBCL in older patients is
associated with comparatively worse outcomes even when accounting for treatment intensity and…
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