grant
Project 3: Cellular and molecular mechanisms underlying effects from early life exposure to HAB toxins
Organization WOODS HOLE OCEANOGRAPHIC INSTITUTIONLocation WOODS HOLE, UNITED STATESPosted 30 Sept 2018Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years old3-D3-Dimensional3DAcuteAdolescentAdolescent YouthAdultAdult HumanAffectAgonistAmnesic shellfish poisonAnatoxinsAnimal ModelAnimal Models and Related StudiesAstrocytesAstrocytusAstrogliaAxonBehavioralBiologic ModelsBiological ModelsBiophysicsBody TissuesBrachydanio rerioBrainBrain Nervous SystemCell BodyCell DifferentiationCell Differentiation processCell-Extracellular MatrixCellsChemical ExposureChildChild YouthChildren (0-21)CollaborationsConsultationsCoupledDanio rerioDevelopmentDevelopmental BiologyDiseaseDisorderECMEmbryoEmbryonicEncephalonEnvironmentEnvironmental ToxinExposure toExpression SignatureExtracellular MatrixFishesFoodGene ExpressionGene Expression ProfileGene TranscriptionGenetic TranscriptionGliaGlial CellsGlutamate ReceptorGonyaulax ToxinGuidelinesHarvestHealthHumanHydrogen OxideIn VitroInduced pluripotent stem cell derived human neuronKolliker's reticulumLarvaLifeLife CycleLife Cycle StagesMitilotoxinModel SystemModelingModern ManMolecularMultipotent Stem CellsNerve CellsNerve UnitNervous SystemNeural CellNeural DevelopmentNeural Stem CellNeurocyteNeurogliaNeuroglial CellsNeurologic Body SystemNeurologic Organ SystemNeuronsNeurophysiology - biologic functionNeurotoxinsNicotinic Acetylcholine ReceptorsNicotinic ReceptorsNon-neuronal cellNonneuronal cellOceanographic scienceOceanographiesOceanographyOceansOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOutcomePCBsPersonsPolychlorinated BiphenylsPolychlorobiphenyl CompoundsPredispositionProbabilistic ModelsProbability ModelsProgenitor CellsProliferatingPublic HealthRNA ExpressionRNA SeqRNA sequencingRNAseqResearchRiskSaxitoninSaxitoxinSea-FoodSeafoodSodium Channel BlockersSourceStatistical ModelsSusceptibilitySynapsesSynapticSystemTargeted ToxinsTestingTimeTissuesToxic Environmental AgentsToxic Environmental SubstancesToxic effectToxicitiesToxinTranscriptionTransgenic OrganismsWaterZebra DanioZebra FishZebrafishadult youthadulthoodastrocytic gliabasebasesbefore conceptionbiophysical foundationbiophysical modelbiophysical principlesbiophysical sciencesbrown tidecell typecellular differentiationcellular targetingcoastal waterconsultationdemoic aciddesigndesigningdevelopmentaldevelopmental neurotoxicitydevelopmental toxicitydevelopmental toxicologydomoic acidearly life exposureenvironmental toxicantexposed human populationgene expression patterngene expression signaturegene regulatory networkglial neural stem cellglial progenitorglial stem cellharmful algal bloomshiPSChiPSC-derived neuronshuman exposurehuman iPShuman iPSChuman iPSC-derived sensory neuronhuman induced pluripotent cellhuman induced pluripotent stem cell derived sensory neuronhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSC-derived human neuronimprovedin vivoinduced human pluripotent stem cellsinducible pluripotent stem cell derived human neuroninducible pluripotent stem cell derived human sensory neuroninsightjuvenilejuvenile humankidslife courselife spanlifespanmarinemarine environmentmodel of animalmodel organismmultipotent progenitormultipotent progenitor cellmyelinationnerve cementnerve stem cellneuralneural circuitneural circuitryneural functionneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurobehavioralneurocircuitryneurodevelopmentneurogenic progenitorsneurogenic stem cellneuroglial progenitorneuroglial stem cellsneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneurons differentiated from human induced pluripotent stem cellsneuroprogenitorneurotoxicneurotoxicantocean sciencesoceanic scienceoceanographic studiesoligodendrocyte differentiationpersistent organic pollutantspolychlorobiphenylpreconceptionprior to conceptionprogenitor and neural stem cellsprogenitor cell differentiationprogenitor differentiationresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstatistical linear mixed modelsstatistical linear modelsstem and progenitor differentiationstem cell differentiationstem cellssynapsesynaptic circuitsynaptic circuitrythree dimensionaltoxicanttranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranscriptomicstransgenicvoltageyoung adultyoung adult ageyoung adulthoodyoungster
Description preview
The overall objective of the proposed research is to elucidate the cellular and molecular mechanisms of toxicity
from developmental exposure to harmful algal bloom (HAB) toxins. The HAB toxins domoic acid (DA), saxitoxin
(STX), and anatoxin-a (ATX-a) occur in marine and coastal water bodies as well as in food sources and pose a
significant…
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