grant
Project 3
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 30 Sept 1997Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025APO2AddressAdhesionsAgeAllelesAllelomorphsAntigen-Presenting CellsAssayAutoimmune StatusAutoimmunityAutomobile DrivingAvidityBioassayBiologic ModelsBiologicalBiological AssayBiological MarkersBiological ModelsBiometricsBiometryBiostatisticsBody TissuesBrittle Diabetes MellitusCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8BCD8B1CD8B1 geneCITE sequencingCITE-seqCITEseqCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Communication and SignalingCell SignalingCell Surface AntigensCell modelCellsCellular Immune FunctionCellular Indexing of Transcriptomes and Epitopes by SequencingCellular biologyCellular modelCirculationClass II AntigensClass II Major Histocompatibility AntigensClinicalClone CellsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemCollaborationsComplexCoupledDR4DataDeath Receptor 4DefectDevelopmentDiseaseDisease ProgressionDisorderDonor ScreeningDonor SelectionElementsEventFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGWA studyGWASGene DeliveryGene ExpressionGene variantGenesGeneticGenetic PolymorphismGenetic RiskGenome engineeringGenotypeHL-A AntigensHLA AntigensHaplotypesHealthHistocompatibility Antigens Class IIHistocompatibility ComplexHistocompatibility ComplicesHumanHuman Leukocyte AntigensHumulin RI-A AntigenIDDMIa AntigensIa-Like AntigensImmuneImmune Response AntigensImmune systemImmune-Response-Associated AntigensImmunesImmunogeneticsImmunologic SubtypingImmunological Surface MarkersImmunomodulationImmunophenotypingIn SituIn VitroIndividualInflammatoryInfrastructureInsulinInsulin-Dependent Diabetes MellitusIntakeIntracellular Communication and SignalingJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnock-outKnockoutKnowledgeLYT3LaboratoriesLeadLeukocyte AntigensLinkLymph Node Reticuloendothelial SystemLymph node properLymphaticLymphatic nodesLytotoxicityMGC9365MHC Class II MoleculeMHC Class II ProteinMHC ReceptorMHC class II antigenMajor Histocompatibility ComplexMajor Histocompatibility Complex Class IIMajor Histocompatibility Complex ReceptorMajor Histocompatibility ComplicesMemoryMetadataMinorModel SystemModern ManMolecularMonitorNatural HistoryNovolin RPancreasPancreaticPathogenesisPathogenicityPathway interactionsPb elementPeptidesPeripheralPhenotypePopulationReceptor ActivationReceptor ProteinReceptor SignalingRegular InsulinRegulationRegulatory T-LymphocyteResistanceRiskRisk FactorsRisk-associated variantSamplingSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSliceSpecificitySpleenSpleen Reticuloendothelial SystemStandardizationSudden-Onset Diabetes MellitusSurfaceSurface AntigensSystemSystems BiologyT Cell SpecificityT cell differentiationT cell receptor repertoire sequencingT cell receptor sequencingT-Cell ActivationT-Cell Antigen ReceptorsT-Cell Immunologic SpecificityT-Cell ReceptorT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT-cell receptor repertoireT1 DMT1 diabetesT1DT1DMT4 CellsT4 LymphocytesTCR repertoireTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTNF-Related Apoptosis Inducing Ligand Receptor 1TNF-related apoptosis-inducing ligand receptor 1TNFRSF10ATNFRSF10A geneTRAIL Receptor 1TRAIL-R4TRAILR-1TRAILR1Teff cellTestingTherapeuticTherapeutic InterventionThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissuesTregTumor Necrosis Factor Receptor Superfamily, Member 10AType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVascular Endotheliumaccessory cellactivate T cellsagesallelic variantarmautoimmune beta cell destructionautoimmune islet destructionautoimmune reactivityautoreactive T cellautoreactivitybeta cell autoimmunitybio-markersbiologicbiologic markerbiological signal transductionbiomarkercell biologycell killingcellular indexing of transcriptomes and epitopes by single cell sequencingcheck point receptorscheckpoint receptorscytotoxicitydata acquisitiondata acquisitionsdata integrationdeath receptor-4developmentaldiabetes pathogenesisdiabetes riskdisease riskdisorder riskdraining lymph nodedrivingeffector T cellflow cytophotometrygenetic variantgenome wide analysisgenome wide associationgenome wide association scangenome wide association studygenome wide studiesgenome-wide analysisgenome-wide identificationgenomewide association scangenomewide association studygenomic variantheavy metal Pbheavy metal leadhigh riskhuman imagingimmune check pointimmune checkpointimmune functionimmune modulationimmune regulationimmunecheckpointimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinsightinsulin dependent diabetesinsulin dependent type 1intervention therapyisletislet autoimmunityislet cell autoimmunityjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteslymph glandlymph nodeslymphnodesmeta datamultiomicsmultiple omicspanomicspathogenpathwayperipheral bloodpolygenetic risk scorespolygenic risk scorepolymorphismprecision medicineprecision-based medicineprogramsprotein complexreceptorreceptor TRAIL-4regional lymph noderegulatory T-cellsresistantrisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqself-reactive T cellsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle nucleotide variantsingle-cell RNA sequencingsynergismtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetumor necrosis factor receptor superfamily member 10Atype I diabetestype one diabeteswhole genome association analysiswhole genome association study
Description preview
The adaptive arm of the human immune system provides exquisite protection from pathogens, but the highly
variable receptors can turn on self-tissues when immunoregulatory checkpoints are broken due to genetic risk
and inflammatory events. A breakdown in tolerance impacting T cells is thought to be a critical immune
checkpoint during the natural…
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