grant

Project 3: Albayram

Organization MEDICAL UNIVERSITY OF SOUTH CAROLINALocation CHARLESTON, UNITED STATESPosted 1 Apr 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202512-20 years old21+ years old95 Leukocyte Surface Antigen P150Acquired brain injuryAdolescenceAdultAdult HumanAffectAlpha Subunit Myeloid Membrane AntigenAlphax Integrin ChainAntigen Cd11c (P150), Alpha PolypeptideApplications GrantsAreaAxb2BehavioralBleedingBrainBrain InjuriesBrain Nervous SystemC3 aC3aCD11bCD11cCD11c AntigensCD18COBRECR3CR3 ReceptorCR3ACell BodyCell Communication and SignalingCell SignalingCellsCenter of Biomedical Research ExcellenceCenters of Research ExcellenceCerebral PalsyChronicCognitiveComplementComplement 3 ReceptorComplement 3aComplement ActivationComplement C3aComplement ProteinsComplement ReceptorCr4DataData SetDevelopmentDiseaseDisorderDysfunctionEncephalonEnsureFailureFunctional disorderFutureGoalsGrant ProposalsHemorrhageHortega cellHydrocephalusHydrocephalyITGAMITGAM geneITGAXITGAX geneITGB2ITGB2 geneImmuneImmune Cell ActivationImmune memoryImmunesImmunologic MemoryImmunological MemoryInfiltrationInjuryIntegrin Alpha XIntegrin alpha-M beta-2Integrin alphaMbeta2Integrin alphaXIntracellular Communication and SignalingInvestigatorsKO miceKnock-out MiceKnockout MiceKnowledgeLCAMBLeu-M5 AntigensLifeLigandsLinkMAC1AMF17MO1AMac 1Mac-1 Adhesive ReceptorMac-1 AntigenMac-1 ReceptorMacrophage-1 AntigenMediatingMedicalMentorsMiceMice MammalsMicrogliaMo1 Antigen ReceptorMo1 Glycoprotein ReceptorModelingMurineMusNational Institutes of HealthNeonatalNeonatal Brain InjuryNerve CellsNerve DegenerationNerve UnitNeural CellNeural DevelopmentNeurocyteNeurodevelopmental DeficitNeurodevelopmental DisorderNeurodevelopmental ImpairmentNeuroimmuneNeurological Development DisorderNeuron DegenerationNeuronsNull MouseOpsoninPathogenicityPathologic ProcessesPathological ProcessesPerinatal subependymal hemorrhagePeriventricular LeukomalaciaPhagocytosisPhasePhenotypePhysiopathologyProcessReceptor ProteinResearch PersonnelResearch ResourcesResearch SupportResearchersResourcesRiskRisk FactorsRisk ReductionRoleSignal TransductionSignal Transduction SystemsSignalingSiteSubependymalSymptomsSynapsesSynapticTestingTherapeuticTimeTrainingUnited States National Institutes of HealthVascularizationadolescence (12-20)adulthoodanamnestic reactionassociated symptombehavioral impairmentbiological signal transductionblood lossbrain cellbrain damagebrain damage in neonatesbrain injury in neonatesbrain-injuredcareer developmentcell typeclinical relevanceclinically relevantco-morbid symptomco-occuring symptomcomorbid symptomcomplement pathway regulationcomplementationconcurrent symptomcooccuring symptomdevelopmentalfetalgerminal matrix hemorrhagegitter cellhydrocephalicimmune activationimpaired behaviorinjuriesinnovateinnovationinnovativeintraventricular hemorrhagemesogliamicroglial cellmicrogliocytemouse modelmurine modelneonatal brainneonateneural degenerationneural inflammationneurobehavioralneurodegenerationneurodegenerativeneurodevelopmentneurodevelopmental diseaseneuroinflammationneuroinflammatoryneurological degenerationneuronalneuronal degenerationnovelpathophysiologyperi-vascular leukomalaciaperivascular glial cellpharmacologicpremature neonatespremature newbornpreterm neonatepreterm newbornreceptorreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresponserisk-reducingsecondary immune responsesocial rolesuccesssymptom associationsymptom comorbiditysynapsetooluptakeαMβ2
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PROJECT 3 – PROJECT SUMMARY
Aberrant secondary immune activity after brain injury during neonatal life affects critical phases of brain

development, with long-lasting behavioral abnormalities relevant to neurodevelopmental disorders. The most

common form of brain injury in the preterm neonate is germinal matrix hemorrhage (GMH), which may display…

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Project 3: Albayram — MEDICAL UNIVERSITY OF SOUTH CAROLINA | UNITED STATES | Apr 2023 | Dev Procure