grant
Project 2 - VLP-based vaccines displaying PorB peptides that induce functional antibodies (CIIG)
Organization HENRY M. JACKSON FDN FOR THE ADV MIL/MEDLocation BETHESDA, UNITED STATESPosted 12 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AdjuvantAlternative Complement PathwayAntibiotic ResistanceAntibodiesAntibody ResponseAntigen VariationAntigenic DeterminantsAntigenic VariabilityAntigenic VariationAntigensBacteriaBacteriophagesBindingBinding DeterminantsBinding ProteinsBlocking AntibodiesBlood SerumCervicalCervicitisCollaborationsComplementComplement ActivationComplement Factor HComplement ProteinsCore FacilityCyclic PeptidesDevelopmentDevelopment PlansEctopic PregnancyEngineeringEpitopesFactor HFearFrightGenerationsGenital OrgansGenitaliaGoalsGonococcal InfectionGonococcusGonorrheaImmuneImmune EvasionImmune responseImmunesImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIncidenceInfectionInterventionLeadLengthLife CycleLife Cycle StagesLigand Binding ProteinLigand Binding Protein GeneMeasuresMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMeningococcusMiceMice MammalsModelingMolecular InteractionMucosaMucosal Immune ResponsesMucosal TissueMucous MembraneMurineMusN gonorrheaN meningitidisN. gonorrheaN. gonorrhoeae vaccineN. meningitidisNeedlesNeisseria gonorrhoeaeNeisseria gonorrhoeae vaccineNeisseria meningitidisPathogenesisPathway interactionsPb elementPelvic Inflammatory DiseasePeptidesPhagesPlayProperdin PathwayProtein BindingRecombinantsRegimenRegulatory ProteinResearchResistanceResistance to antibioticsResistant to antibioticsRoleSerumServicesSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionSpecificitySurfaceSurface ProteinsTechniquesTestingUnited StatesUrethritisVDAC1VDAC1 geneVaccine ProductionVaccinesVenereal DiseasesVenereal DisordersVenereal InfectionsVirus-like particleWorkantibiotic drug resistanceantibiotic resistantbacterial virusbactericidalbactericidebound proteincell bankchemical conjugatechronic pelvic floor painchronic pelvic painchronic pelvic pain syndromecombatcomplement pathway regulationcomplementationdeliver vaccinesdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalexperienceextracellularextrauterine pregnancyflexibilityflexiblegenetic regulatory proteingenital infectiongenital tractgonorrhea vaccineheavy metal Pbheavy metal leadhost responsehuman pathogenimmune evasiveimmune modulationimmune modulatory interventionimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunogenimmunogenicimmunogenicityimmunointerventionimmunologic reactivity controlimmunological interventionimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinfection rateinhibiting antibodylife coursemanufacturemembrane structurenovelpathwaypelvic inflammation diseasepelvic inflammation disorderpelvic inflammatory disorderpelvic inflammatory syndromepelvic myofascial painpore forming proteinporinpreventpreventingproduce vaccinesproduct developmentrate of infectionrecombinant virusregulatory gene productreproductive tractresistance strainresistantresistant strainsexually acquired infectionsocial roletechnology platformtechnology systemtooltubal factor infertilitytubal infertilityvaccine against N. gonorrhoeaevaccine against Neisseria gonorrhoeaevaccine antibodiesvaccine candidatevaccine candidates for Neisseria gonorrhoeaevaccine deliveryvaccine developmentvaccine efficacyvaccine induced antibodiesvaccine platformvaccine-induced antibodiesvirus-like nanoparticlesviruslike particle
Description preview
PROJECT SUMMARY
Neisseria gonorrhoeae (Ng) is an obligate human pathogen that causes gonorrhea, one of the most common
sexually transmitted infections. The incidence of Ng infection in the United States is rising, and the emergence
of multi-antibiotic resistant strains have led to fears that treatment options for gonorrhea are decreasing. The…
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