grant
Project 2: Pre-Clinical Models and Phage Pharmacodynamics
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026Ab responseAcuteAddressAirway infectionsAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody FormationAntibody ProductionAssayBacteria resistanceBacteria resistantBacterial InfectionsBacterial resistantBacteriophagesBioassayBiological AssayBody TissuesCF airwayCF lung diseaseCF patientsCFTRCFTR ProteinChronicClinicalCommon Rat StrainsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDevelopmentDoseDrug or chemical Tissue DistributionDysfunctionESKAPEESKAPE pathogensEvaluationFunctional disorderGeneticGenomicsGoalsHourImmune responseImmunologyImpairmentInflammationInhalationInhalingInnate Immune ResponseKnock-outKnockoutLabelLong-term infectionLungLung Respiratory SystemLung infectionsLyticMath ModelsMeasuresMiceMice MammalsMicrobial BiofilmsMicrobiologyModelingMucociliary ClearanceMucociliary TransportMucoviscidosisMurineMusP aeruginosaP. aeruginosaPersonsPhagesPharmaceutical AgentPharmaceuticalsPharmacodynamicsPharmacologic SubstancePharmacological SubstancePharmacologyPhysiologicPhysiologicalPhysiopathologyPre-Clinical ModelPreclinical ModelsPreparationProtocolProtocols documentationPseudomonas aeruginosaPseudomonas pyocyaneaPulmonary Cystic FibrosisRatRats MammalsRattusRegimenReproducibilityResistanceRespiratory InfectionsRespiratory Tract InfectionsRouteScheduleSiteStandardizationStudy modelsTestingTherapeuticTherapeutic StudiesTherapy ResearchTissue DistributionTissuesTreatment EfficacyTreatment outcomeWorkadaptive immunityantibody biosynthesisbacteria infectionbacterial diseasebacterial resistancebacterial virusbiofilmchronic infectioncystic fibrosis airwaycystic fibrosis lungcystic fibrosis lung diseasecystic fibrosis patientscystic fibrosis transmembrane regulatorcytokinedensitydesigndesigningdevelop therapydevelopmentalhost responseimmune system responseimmunoglobulin biosynthesisimmunoresponsein vivoindividuals with CFindividuals with cystic fibrosisintervention developmentintervention efficacymathematic modelmathematical modelmathematical modelingmembermodel of animalpathophysiologypatients with CFpatients with cystic fibrosispersistent infectionpharmaceuticalpre-clinicalpreclinicalpreparationsprogramspulmonary infectionsrepurposingresistance to Bacteriaresistance to Bacterialresistantresistant to Bacteriaresistant to Bacterialrespiratoryresponsesuccesstherapeutic efficacytherapy developmenttherapy efficacytooltreatment development
Description preview
ABSTRACT SUMMARY
Airway infections in people with Cystic Fibrosis (CF) evolve over months to years and are characterized by
chronic inflammation, bacterial biofilms, and impaired mucociliary clearance. Ideally, it would be possible to
develop phage therapy in pre-clincial models that recapitulate aspects of this pathophysiology.
Unfortunately,…
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