grant
Project 2: Novel investigation of Epstein-Barr virus as a potential cause of conjunctival squamous cell carcinoma among people living with HIV in Zimbabwe
Organization H. LEE MOFFITT CANCER CTR & RES INSTLocation TAMPA, UNITED STATESPosted 3 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS associated cancerAIDS related cancerAIDS-Related MalignancyAIDS-Related Malignant NeoplasmAIDS-associated malignanciesAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAfrica South of the SaharaAgeAntibodiesB7-H1BenignBiological MarkersBlindnessBloodBlood Reticuloendothelial SystemBody TissuesBurkitt HerpesvirusBurkitt Lymphoma VirusCD152CD152 AntigenCD152 GeneCD274CD3CD3 AntigensCD3 ComplexCD3 moleculeCD8CD8BCD8B1CD8B1 geneCTLA 4CTLA-4 GeneCTLA4CTLA4 geneCTLA4-TMCancer CauseCancer EtiologyCancersCarcinomaCausalityCell BodyCellsCervical CancerCervix CancerClinicClinicalConjunctival Epidermoid CarcinomaConjunctival Squamous Cell CarcinomaCutaneousCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4DNA analysisDataDetectionDevelopmentDiagnosisEB virusEBVEBV InfectionsEBV malignanciesEBV(+) malignancyEBV-Related MalignancyEBV-associated cancersEBV-associated malignancyEBV-positive cancerEBV-positive malignancyEBV-positive malignant tumorEBV-related cancerEarly DiagnosisEconomicsEnrollmentEpithelial cancerEpstein Barr VirusEpstein Barr Virus MalignancyEpstein Barr Virus associated cancersEpstein Barr Virus positive cancerEpstein-Barr Virus InfectionsEpstein-Barr Virus associated malignancyEpstein-Barr Virus-Related MalignancyEpstein-Barr Virus-Related Malignant NeoplasmEpstein-Barr viral infectionsEtiologyEvaluationExclusionEyeEye CancerEyeballFOXP3FOXP3 geneForkhead Box P3FrequenciesFutureGene TranscriptionGenetic TranscriptionGoalsGroupingHHV-4HHV4HIVHIV InfectionsHIV-Associated CancerHIV-associated malignancyHIV-related malignancyHIV/AIDS-associated malignancyHIV/AIDS-related cancerHPVHTLV-III InfectionsHTLV-III-LAV InfectionsHigh PrevalenceHospitalsHouseholdHuman Herpesvirus 4Human Immunodeficiency VirusesHuman Papilloma VirusHuman PapillomavirusHuman T-Lymphotropic Virus Type III InfectionsIARCImmuneImmune MarkersImmune infiltratesImmune responseImmunesImmunologic MarkersImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIncidenceIndividualInfection ControlInfectious Human Wart VirusInfectious Mononucleosis VirusInternational Agency for Research on CancerInvestigationJM2Kaposi SarcomaKaposi's SarcomaLAV-HTLV-IIILYT3LaboratoriesLesionLinkLymphadenopathy-Associated VirusMalignantMalignant - descriptorMalignant Cervical NeoplasmMalignant Cervical TumorMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant Eye NeoplasmMalignant Neoplasm of the CervixMalignant NeoplasmsMalignant Ocular NeoplasmMalignant Ocular TumorMalignant TumorMalignant Tumor of the CervixMalignant Tumor of the Cervix UteriMalignant Tumor of the EyeMalignant Uterine Cervix NeoplasmMalignant Uterine Cervix TumorMalignant neoplasm of cervix uteriMeasuresMorbidityMorbidity - disease rateMultiple Hemorrhagic SarcomaOKT3 antigenOncologyOncology CancerOphthalmologic Surgical ProceduresOphthalmological SurgeryOphthalmological Surgical ProceduresOutcomePD 1PD-1PD-L1PD1PDL-1ParticipantPatientsPatternPersonsPopulationPredispositionPrevalencePreventiveProductivityProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1Public HealthRNA ExpressionReportingResearchResearch SpecimenRiskRisk FactorsRoleSCURFINSouthern RhodesiaSpecimenSub-Saharan AfricaSubsaharan AfricaSusceptibilityT-CellsT-LymphocyteT3 AntigensT3 ComplexT3 moleculeTestingTimeTissuesTranscriptionTranslatingTumor TissueTumor-infiltrating immune cellsUterine Cervix CancerViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirusVirus DiseasesVirus-HIVVirus-Related MalignancyVirus-Related Malignant NeoplasmVital StatusZimbabweZimbabwe Rhodesiaadvanced diseaseadvanced illnessagesanalyze DNAbio-markersbiobankbiologic markerbiological sexbiological specimen archivesbiomarkerbiorepositorybiosample archivebiospecimen archivecancer riskcausationcompare to controlcomparison controlconjunctiva epidermoid carcinomaconjunctiva squamous cell carcinomacytotoxic T-lymphocyte antigen 4developmentaldisease causationearly biomarkersearly detectionearly detection biomarkersearly detection markerseconomicenrollepithelial carcinomaexhaustioneye surgerygroupingshost responseimmune cell infiltrateimmune cell infiltration of tumorsimmune cells infiltrating the tumorimmune cells that infiltrate the tumorimmune check pointimmune checkpointimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune-based biomarkersimmunecheckpointimmunological biomarkersimmunological markersimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinfiltration of tumors by immune cellsintratumoral immune cellintratumoral immune infiltratemalignancymalignant neoplasm of eyemortalityneoplasm/cancernovelprogrammed cell death 1programmed cell death ligand 1programmed cell death protein 1programmed cell death protein ligand 1programmed death 1protein death-ligand 1sexsle2social rolespecimen archivesystemic lupus erythematosus susceptibility 2targeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetumortumor immune celltumor immune infiltratetumor infiltration of immune cellsviral DNAviral associated cancerviral associated malignancyviral associated malignant neoplasmviral detectionviral induced cancerviral induced malignancyviral induced malignant neoplasmviral infectionviral related cancerviral related malignancyviral related malignant neoplasmvirus DNAvirus associated cancervirus associated malignancyvirus associated malignant neoplasmvirus detectionvirus induced cancervirus induced malignancyvirus induced malignant neoplasmvirus infectionvirus proteinvirus related cancervirus-induced diseasevision lossvisual losswart virus
Description preview
PROJECT SUMMARY – PROJECT 2 Conjunctival squamous cell carcinoma (cSCC) is an eye cancer with unknown etiology. cSCC disproportionately impacts Sub-Saharan Africa (SSA), a setting where presentation with advanced disease is common. This translates into a high morbidity burden, as treatment of advanced cSCC includes destructive eye surgery leading…
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