grant
Project 2: Molecular mechanisms of acute ethanol behaviors in C. elegans
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 5 Aug 2014Deadline 31 May 2030
NIHUS FederalResearch GrantFY202521+ years oldAbsolute ethanolAcidsAcuteAdultAdult HumanAffectAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAnabolismAnimalsBehaviorBehavioralBilayer FluidityBinding ProteinsBiologicalBiological FunctionBiological ProcessBiologyBiophysicsC elegansC. elegansC.elegansCaenorhabditis elegansCandidate Disease GeneCandidate GeneCell BodyCellsCellular MembraneCollaborationsDNA mutationDevelopmentDietDrugsETOHEicosapentaenoic AcidEnvironmentEnvironmental FactorEnvironmental Risk FactorEtOH drinkingEtOH useEthanolEthyl AlcoholFundingFutureGWA studyGWASGenesGeneticGenetic ChangeGenetic DiversityGenetic ModelsGenetic VariationGenetic defectGenetic mutationGrain AlcoholHumanImpulsive BehaviorIndividualInvestigationInvestigatorsLigand Binding ProteinLigand Binding Protein GeneLipidsMeasuresMediatingMedicationMembraneMembrane FluidityMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolic Protein DegradationMethylcarbinolMiceMice MammalsModelingModern ManMolecularMurineMusMutationN-3 polyunsaturated fatty acidNematodaNematodesNerve CellsNerve UnitNeural CellNeurocyteNeuronsOmega-3 Fatty AcidsOmega-3 PUFAOmega-3 Polyunsaturated Fatty AcidOmega3OrganismOrthologOrthologous GenePathway interactionsPharmaceutical PreparationsPhenotypePhysiologicPhysiologicalPlayPolyunsaturated Fatty AcidsPositionPositioning AttributePredispositionPredisposition geneProcessProtein BindingProtein TurnoverRegulatory Protein DegradationResearchResearch PersonnelResearchersRisk BehaviorsRisky BehaviorRodentRodentiaRodents MammalsRoleSurface ProteinsSusceptibilitySusceptibility GeneTestingTimeTimnodonic AcidVariantVariationWorkadulthoodalcohol behavioralcohol effectalcohol exposedalcohol exposurealcohol induced behavioralcohol ingestionalcohol intakealcohol product usealcohol related behavioralcohol responsealcohol sensitivityalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeat risk behavioraxon growth cone guidanceaxon guidanceaxonal pathfindingbehavior phenotypebehavior responsebehavioral phenotypingbehavioral responsebiologicbiophysical foundationbiophysical principlesbiophysical sciencesbiosynthesisbound proteindevelopmentaldietarydietsdrug/agenteicosapentanoic acidendophenotypeenvironmental riskethanol behaviorethanol consumptionethanol drinkingethanol effectethanol exposedethanol exposureethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol related behaviorethanol responseethanol sensitivityethanol useethanol use disorderexperimentexperimental researchexperimental studyexperimentsexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolexternalizing behaviorfat metabolismfeedingforward geneticsgene functiongene networkgenetic analysisgenetic approachgenetic strategygenome mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyinsightlipid metabolismlipidomicsliving systemloss of function mutationmembrane structuremutantn-3 Fatty Acidsn-3 PUFAneuronalnovelomega-3omega-3spathwaypharmacologicpredisposing geneprotein degradationprotein functionresponseresponse to alcoholresponse to ethanolreverse geneticsroundwormscreeningscreeningssensitivity to alcoholsensitivity to ethanolsocial rolespatial and temporalspatial temporalspatiotemporalsuccesssusceptibility allelesusceptibility locussusceptibility varianttranscriptomicstranslational studywhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY
The development of alcohol use disorder (AUD) is strongly influenced by both genetics and environment. Here
we seek to test several hypotheses that relate to both genetic and environmental influences on the level of
response (LR) to alcohol. LR is an acute measure that is a strong endophenotype for predisposition to develop
AUD.…
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