grant
Project 2 - Longitudinal study of complement-mediated TMA
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 15 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20250-11 years old19S Gamma Globulin21+ years oldAcuteAdultAdult HumanAlternative Complement PathwayApoplexyAreaAssayAutoantibodiesAutoimmune StatusAutoimmunityBioassayBiological AssayBiosensorBiotechBiotechnologyBlood SerumBlood VesselsBrain Vascular AccidentCancersCardiac DeathCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell LineCellLineCellsCellular injuryCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeChildChild YouthChildren (0-21)ClinicalClinical DataComplementComplement ActivationComplement Factor HComplement InactivatorsComplement InhibitorsComplement ProteinsDNA mutationDataDeathDiagnosisDiseaseDisease remissionDisorderESKDESRDEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEndotheliumEvaluationEventExclusionExhibitsFactor HGasser's SyndromeGenetic ChangeGenetic DiseasesGenetic defectGenetic mutationGerm LinesGerm-Line MutationGestationGoalsHealthHeart VascularHemolytic-Uremic SyndromeHereditary MutationHypertensionIgMImmunoglobulin MIndividualInfectionInflammationInjuryKidneyKidney DiseasesKidney Urinary SystemLectinLongitudinal StudiesMalignant NeoplasmsMalignant TumorMeasuresMediatingMonitorMutationMyocardial InfarctMyocardial InfarctionNatural HistoryNephropathyNeurologicNeurologic outcomeNeurologicalNeurological outcomeOutcomeParticipantPathogenicityPathway interactionsPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPenetrancePhasePlatelet ActivationPositionPositioning AttributePregnancyProperdin PathwayQOLQuality of lifeRegistriesRelapseRemissionRenal DiseaseRenal functionResistant HypertensionRiskRoleSeminalSerumStrains Cell LinesStrokeTherapeuticThrombosisTimeUncertaintyVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderWorkadulthoodautoimmune antibodyautoimmune reactivityautoreactive antibodyautoreactivitybiological sensorbrain MR imagingbrain MRIbrain attackbrain magnetic resonance imagingcardiac MRIcardiac infarctcardiac magnetic resonance imagingcardiovascular disordercell damagecell injurycellular damagecerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcerebral vascular accidentcerebrovascular accidentcirculatory systemclinical remissionclinical research siteclinical siteco-morbidco-morbiditycohortcomorbiditycomplement pathwaycomplement pathway regulationcomplementationcoronary attackcoronary infarctcoronary infarctioncultured cell linedamage to cellsdefined contributiondepositorydoubtgene complementationgenetic conditiongenetic disordergenome mutationgerm-line defectgermline variantheart attackheart infarctheart infarctionhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedinhibitorinjuriesinjury to cellsischemia injuryischemic injurykidney disorderkidney functionkidslong-term sequelaelong-term studylongitudinal outcome studiesmalignancyneoplasm/cancernovelpathwayprospectiverelapse riskrenalrenal disorderrepositoryself reactive antibodysocial rolestrokedstrokesthromboembolic complicationsthrombosis complicationsthrombotic complicationsthrombotic diseasethrombotic disorderunclassified variantvariant of uncertain clinical significancevariant of uncertain significancevariant of undetermined significancevariant of unknown significancevascularyoungster
Description preview
PROJECT SUMMARY – PROJECT 2
The overall goal of this project is to develop the first multicenter, prospective, longitudinal natural history study
of complement-mediated TMA (CM-TMA also called atypical hemolytic uremic syndrome) to comprehensively
investigate short- and long-term outcomes including renal, cardiovascular, neurologic, and patient…
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