grant
Project 2: Local and global epigenome regulation of senescence and aging
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAcetyl CoAAcetyl Coenzyme AAcetylationAgeAgingAnimal ModelAnimal Models and Related StudiesAutomobile DrivingAutophagocytosisAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBody TissuesCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancrum OrisCell BodyCell Communication and SignalingCell FunctionCell NucleusCell PhysiologyCell ProcessCell Senescence InductionCell SignalingCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelChromatinCoinCollaborationsCommunitiesComplexCytoplasmDataDeteriorationDiseaseDisorderDrug TherapyDysfunctionEnhancersEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEukaryotaEukaryoteFunctional disorderFundingGangrenous StomatitisGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionHistone AcetylaseHistone AcetylationHomeostasisHumanImmunoglobulin Enhancer-Binding ProteinInflammatoryIntervening SequencesIntracellular Communication and SignalingIntronsLength of LifeLinkLiverLongevityMaintenanceMediatingMetabolicMetabolic PathwayMiceMice MammalsModelingModern ManMolecular InteractionMurineMusNF-kBNF-kappa BNF-kappaBNFKBNomaNuclearNuclear Factor kappa BNuclear Transcription Factor NF-kBNucleusPathway interactionsPharmacological TreatmentPharmacotherapyPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlayProcessPyruvateRNA ExpressionRegulationRegulatory PathwayResearchRoleS-acetate Coenzyme ASeminalSignal TransductionSignal Transduction SystemsSignalingSomatic MutationStimulator of Interferon GenesSubcellular ProcessTimeTissuesTranscriptionTranscription Factor NF-kBTranscription Factor Proto-OncogeneTranscription InitiationTranscription factor genesage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentagesaging associatedaging induced epigenetic changeaging relatedaging-associated epigenetic changeaging-related epigenetic changeattenuation of senescenceautophagybiological signal transductioncGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcellular aging inductioncellular senescence inductionclustered regularly interspaced short palindromic repeats screencyclic GMP-AMP synthase/STINGdecline in functiondecline in functional statusdecrease senescencedelay senescencedrivingdrug interventiondrug treatmentenhance healthspanepigenetic agingepigenetic mechanisms in agingepigenetic modifications in agingepigenetic regulation of agingepigeneticallyepigenomeextend healthspanextending healthy lifespanfunctional declinefunctional status declinegenetic approachgenetic strategyhealthspan extensionhealthy aginghealthy human aginghepatic body systemhepatic organ systemhistone acetyltransferaseimprove healthspanimprovedincrease healthspankappa B Enhancer Binding Proteinliver functionmodel of animalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-geneticnongeneticnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetnuclear factor kappa betapathophysiologypathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprolong healthspanpromote healthspanpromoterpromotorrecruitreduce senescencereducing cellular senescencerepress senescencesenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescence inductionsenescence mitigationsenescentsenescent associated secretomesenescent associated secretory phenotypesocial rolesomatic variantsuppress senescencethree dimensionaltranscription factor
Description preview
ABSTRACT
Studies in animal models reveal that genetic differences and somatic mutations underlie longevity, but that
non-genetic contributions play a major role. Numerous observations, including from this PPG point to
epigenetic alterations in chromatin as having a crucial role both in senescence and in aging. However, key
questions remain, in…
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