grant
PROJECT 2: INNATE IMMUNITY
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV vaccineAP-1AP-1 Enhancer-Binding ProteinAP1AP1 proteinActivator Protein-1Adaptive Immune SystemAddressAdjuvantAttenuated VaccinesBNT 162b2BNT162b2Basal Transcription FactorBasal transcription factor genesBehaviorBloodBlood Reticuloendothelial SystemBlood monocyteBody TissuesBreakbone Fever VirusCOVID-19COVID-19 infectionCOVID-19 vaccinationCOVID-19 vaccineCOVID-19 virusCOVID-19 virus infectionCOVID19 infectionCOVID19 virusCV-19Cell BodyCell LineageCellsChromatinCoV-2CoV2Coronavirus Infectious Disease 2019DENVDendritic CellsDengue VirusDengue fever virusEnhancer-Binding Protein AP1EpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionExposure toFrequenciesGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGrantH5N1H5N1 virusHealth Care ProvidersHealth PersonnelHumanIFNImmuneImmune memoryImmune responseImmunesImmunityImmunizationImmunologic MemoryImmunologic ReceptorsImmunological MemoryImmunological ReceptorsIn VitroInfectionInflammatoryInfluenza A H5N1Influenza A Virus, H5N1 SubtypeInfluenza VaccinesInnate Immune SystemInnate ImmunityInterferonsKO miceKnock-out MiceKnockout MiceLigandsLive-attenuated VaccineLymphatic TissueLymphoid TissueMarrow monocyteMemoryMiceMice MammalsModern ManMucosaMucosal TissueMucous MembraneMurineMusMyelogenousMyeloidMyeloid CellsNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNull MouseOrgan DonorPBMCPeripheral Blood Mononuclear CellPfizer covid19 vaccinePfizer-BioNTech COVID-19 vaccinePfizer-BioNTech coronavirus disease 2019 vaccinePfizer/BioNTech vaccineRNA ExpressionRNA immunizationRNA vaccinationReceptor ProteinResearch ResourcesResistance to infectionResourcesSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 infectionSARS-CoV-2 vaccinationSARS-CoV-2 vaccineSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 vaccineSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 vaccineSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 vaccinationSevere acute respiratory syndrome coronavirus 2 vaccineSevere acute respiratory syndrome related corona virus 2TimeTissuesTrainingTranscriptionTranscription Factor AP-1Transcription Factor Proto-OncogeneTranscription factor genesVaccinationVaccinesVeiled CellsVirusWuhan coronavirusZIKVZika Virusacquired immune systemafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionagedanalyzing longitudinalanamnestic reactionavian influenza H5N1avian influenza H5N1 virusbiological systemscell typecohortcoronavirus disease 2019coronavirus disease 2019 infectioncoronavirus disease 2019 vaccinationcoronavirus disease 2019 vaccinecoronavirus disease 2019 viruscoronavirus disease-19coronavirus disease-19 vaccinecoronavirus disease-19 viruscoronavirus infectious disease-19cytokineepigeneticallyepigenomicsflu vaccineflu virus pandemicflu virus vaccinefollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectionhCoV19health care personnelhealth care workerhealth providerhealth workforcehost responseimmune receptorimmune system responseimmunoresponseimprintinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection resistanceinfluenza virus pandemicinfluenza virus vaccinelive vaccinelive vaccineslongitudinal analysismRNA immunizationmRNA vaccinationmedical personnelmonocytenCoV vaccinenCoV-19 vaccinenCoV19 vaccinenCoV2non-human primatenonhuman primatenovelpandemicpandemic diseasepandemic flupandemic influenzapandemic strain of influenzapathogenpost SARS-CoV-2 infectionprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionreceptorresponsescATAC sequencingscATAC-seqsecondary immune responsesingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell analysissingle cell sequencing assay for transposase accessible chromatinsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqtranscription factortreatment providervaccinate against COVID-19vaccinate against SARS-CoV-2vaccinate against coronavirus disease 2019vaccinate against severe acute respiratory syndrome coronavirus 2vaccination against COVID-19vaccination against SARS-CoV-2vaccination against Severe acute respiratory syndrome coronavirus 2vaccination against coronavirus disease 2019vaccine against 2019-nCovvaccine against COVID-19vaccine against SARS-CoV-2vaccine against SARS-coronavirus-2vaccine against Severe Acute Respiratory Syndrome CoV 2vaccine against Severe acute respiratory syndrome coronavirus 2vaccine against fluvaccine against influenzavaccine candidates against SARS-CoV-2vaccine for novel coronavirusvaccines preventing COVIDvaccines to prevent COVIDzikav
Description preview
ABSTRACT
Immunological memory is a fundamental feature of the adaptive immune system. However emerging evidence
demonstrates that the innate immune system can also display a form of adaptive, memory-like behavior, a
phenomenon termed “trained immunity.” Recently using single cell ATAC-seq we demonstrated that
immunization of humans with the…
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