grant
Project 2: Immune Response Analysis
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 1 Jun 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202521+ years oldAIDSAIDS VirusAccelerationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAdultAdult HumanAffinityAnimal ModelAnimal Models and Related StudiesAntibodiesAntigenic DeterminantsAntigensB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBar CodesBinding DeterminantsBioinformatics coreBioinformatics research coreBioinformatics resource coreCell BodyCellsClass SwitchingClass SwitchingsClassificationClinical Treatment MoabClinical TrialsDevelopmentEnsureEpitope MappingEpitopesEvaluationFeedbackGeneticGoalsHIVHIV vaccineHIV/AIDS VaccinesHumanHuman Immunodeficiency VirusesImmuneImmune responseImmunesImmunityImmunizationImmunizeImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsIsotype SwitchingIsotype SwitchingsKI miceKnock-in MouseLAV-HTLV-IIILeukapheresisLeukocytapheresisLymphadenopathy-Associated VirusMissionModern ManModernizationMonoclonal AntibodiesPatternPhenotypeProcessProteomicsResearch ResourcesResolutionResourcesSamplingSeriesSpecificitySpeedSystematicsTechniquesTechnologyTestingTherapeutic LeukopheresisTimeVaccine DesignVaccinesVirus-HIVVisualization softwareadulthoodbarcodecohortcross reactivitydata integrationdata managementdata sharingdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalevaluate vaccinesexperimentexperimental researchexperimental studyexperimentsgenetic analysishost responsehuman immunodeficiency virus vaccinehumanized micehumanized mouseimmune system responseimmunogenimmunogenicityimmunoresponseimprovedinformatics toolknockin micemAbsmodel of animalmonoclonal Absmouse modelmultiomicsmultiple omicsmurine modelneutralizing antibodynovelpandemicpandemic diseasepanomicsparallelizationresolutionsresponsesuccesstime intervaltime usevaccine developmentvaccine evaluationvaccine screeningvaccine testingvisualization tool
Description preview
PROJECT SUMMARY
The purpose of this Project is to apply advanced multi-omics techniques to comprehensively analyze humoral
immune responses to promising HIV vaccine immunogens. Our mission is to advance vaccine development by
extracting as much information as possible from each immunization trial to best inform the optimal design,
composition and…
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