grant
Project 2- Hydroxocobalamin Study
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20250-11 years old0-4 weeks old21+ years oldAdherenceAdultAdult HumanAgeBiochemicalBlindnessBlood PlasmaCaringCase SeriesCase StudyCharacteristicsChildChild YouthChildhoodChildren (0-21)ClinicalClinical TrialsCobalaminCollaborationsDataDevelopmentDevelopmental DelayDevelopmental Delay DisordersDiagnosisDiseaseDisorderDoseDrugsEXTMREarly DiagnosisExtramuralExtramural ActivitiesFormulationFutureGenotypeGuidelinesHomocysteineHydroxocobalaminHydroxycobalaminIndividualInfantInsuranceLeadMedicationMetabolic ControlMethionineMethylmalonic AcidMonitorNational Institutes of HealthNeonatal ScreeningNeurologicNeurologicalNewborn InfantNewborn Infant ScreeningNewbornsNewly DiagnosedOutcomeParticipantPatientsPb elementPharmaceutical PreparationsPhenotypePlasmaPlasma SerumPopulation HeterogeneityRegimenResearchReticuloendothelial System, Serum, PlasmaSafetySpecific Child Development DisordersSupplementationTestingUnited States National Institutes of Healthadulthoodagescase reportclinical phenotypedevelopmentaldisorder of macula luteadisorder of macula of retinadiverse populationsdrug/agentearly detectionheavy metal Pbheavy metal leadheterogeneous populationimprovedimproved outcomeinfancyinfantilekidsmacula abnormalitymacula lutea abnormalitymacular diseasemacular disordermaculopathymetabolic phenotypemetabotypemethyl-propanedioic acidneonatenewborn childnewborn childrennewborn screeningpatient populationpediatricpopulation diversityrecruitresponsescreening programvision lossvisual lossyoungster
Description preview
ABSTRACT – PROJECT 2 (HYDROXOCOBALAMIN DOSE & COBALAMIN C DISEASE)
State newborn screening programs, which typically include Cobalamin C Disease, facilitate the early diagnosis
and initiation of hydroxocobalamin therapy in newborns with this disorder. Hydroxocobalamin administration
reduces the plasma levels of elevated metabolites (methylmalonic…
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