grant
Project 2: Ex Vivo Modeling and Analysis of Gastric Precancerous Lesions
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 20 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAnatomic SitesAnatomic structuresAnatomyAntibiotic AgentsAntibiotic DrugsAntibioticsApicalAtrophicAtrophyBacterial GenesBasic ResearchBasic ScienceBehaviorBiologicalBiologyBiopsyBody TissuesC pyloriC. pyloriCRISPRCRISPR/Cas systemCampylobacter pyloriCancer CauseCancer EtiologyCancer InductionCancersCarcinomaCategoriesCell CommunicationCell InteractionCell PolarityCell modelCell-to-Cell InteractionCellular biologyCellular modelCessation of lifeChronicClustered Regularly Interspaced Short Palindromic RepeatsCollectionConfocal MicroscopyCorrea cascadeDNA AlterationDNA Sequence AlterationDNA mutationDataDeathDevelopmentDisease ProgressionDysplasiaEndoscopic BiopsyEpithelial CellsEpithelial cancerEpitheliumExperimental ModelsExposure toExpression SignatureFundic GlandGastric Body CancerGastric CancerGastric CarcinomaGastric Cardia CancerGastric Fundus CancerGastric GlandsGastric InflammationGastric Pylorus CancerGastric TissueGastritisGene ExpressionGene Expression ProfileGeneralized GrowthGenesGenetic AlterationGenetic ChangeGenetic defectGenetic mutationGenotypeGlandGrowthH pyloriH pylori infectionH pyloryH. pyloriH. pylori infectionH. pyloryHelicobacter InfectionsHelicobacter Pylori InfectionHelicobacter pyloriHumanImmune responseIn SituIn VitroInfectionInflammationInflammatoryInitiation FactorsIntestinalIntestinal metaplasia of the stomachIntestinesInvestigatorsLaboratory ResearchLesionLibrariesLocationLong-term infectionMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant Gastric NeoplasmMalignant Gastric TumorMalignant NeoplasmsMalignant TumorMeasuresMethodsMicroscopyMiscellaneous AntibioticModelingModern ManMolecularMonitorMutationNGS MethodNGS systemNeoplastic Colony-Forming UnitsNeoplastic Stem CellsOrganoidsPathogenesisPathogenicity FactorsPatientsPeptide Initiation FactorsPersonsPhenotypePrecancerous ConditionsPremalignant ConditionPremalignant StateProcessProgenitor CellsPropertyQuantitative MicroscopyRecrudescencesResearchResearch PersonnelResearch ResourcesResearchersResolutionResourcesRiskRisk FactorsRisk MarkerRoleSamplingSequence AlterationSiteStem Cell ResearchStem Cell likeStomachStomach CancerStomach CarcinomaSurfaceSystemTechniquesTestingTimeTissue GrowthTissue ModelTissuesTranslation Initiation FactorTranslational Initiation FactorTumor Stem CellsVirulence FactorsVisualizationbiologicbowelcancer progressioncarcinogenesiscell biologycellular polaritychronic infectiondevelopmentaldyscrasiaepithelial carcinomaepithelial progenitorepithelial progenitor cellepithelial stem cellexperimentexperimental researchexperimental studyexperimentsfitnessgastricgastric intestinal metaplasiagastric malignancygastric organoidsgastric progenitorgastric stem cellgastroidgene editing methodgene editing methodologygene editing strategygene editing techniquesgene expression patterngene expression signaturegene-editing approachgenetic selectiongenome mutationgenomic alterationhigh riskhost responsehuman tissueimmune system responseimmunoresponseimprovedinsightmalignancymalignant stomach neoplasmmalignant stomach tumormortalityneoplasm progressionneoplasm/cancerneoplasticneoplastic progressionnext gen sequencingnext generation sequencingnextgen sequencingnovelontogenypersistent infectionprecancerprecancerousprecancerous statepremalignantprogenitor capacityprogenitor cell likeprogenitor cell nicheprogenitor cell poolprogenitor cell populationprogenitor nicheprogenitor poolprogenitor populationprogenitor-likeprogramsresolutionsresponserisk predictorrisk predictorsrisk stratificationscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestemstem and progenitor cell nichestem and progenitor cell populationstem cell characteristicsstem cell nichestem cell organoidsstem cell poolstem cell populationstem cell studystem cell-derived organoidsstem cellsstem-likestemnessstomach fundus cancerstomach organoidstomach progenitorstomach pylorus cancerstomach stem cellstratify riskthree dimensionaltissue culturetranscriptional profiletranscriptional signaturetumor progenitortumor progression
Description preview
ABSTRACT – PROJECT 2
The central purpose of Project 2 is to utilize a primary human tissue model to investigate the features of gastric
stem cells and how the cells interact with Helicobacter pylori (Hp). Hp commonly triggers an inflammatory
process that leads to gastric intestinal metaplasia (GIM), a condition that can evolve into invasive…
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