grant
Project 2 - Development of HLA-E-peptide antibodies for enhancing NK and CD8 killing of HIV infected CD4 T cells in vivo
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 18 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AI based modelAI modelAIDSAIDS VirusAb-dependent cellular cytotoxicityAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAcuteAffinityAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody AffinityB cell receptorB-Cell Antigen ReceptorBLT humanized miceBLT humanized mouseBLT miceBLT mouseBindingBiochemicalBody TissuesCAR T cellsCAR modified T cellsCAR-TCAR-TsCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCD94CMVCell BodyCell Communication and SignalingCell SignalingCell TherapyCell-Mediated CytolysisCell-Mediated LympholysisCellsCellular AssayCellular CytotoxicityClinical Treatment MoabComplementComplement ProteinsComplexComputer ModelsComputerized ModelsCoupledCytolysisCytomegalovirusCytotoxic cellDNADNA TherapyDataDeoxyribonucleic AcidDevelopmentEngineeringEnsureEquilibriumGene Transfer ClinicalGenetic InterventionGoalsHCMVHIVHIV InfectionsHIV SeronegativitiesHIV SeronegativityHIV negativeHIV therapyHP40 GeneHTLV-III InfectionsHTLV-III SeronegativitiesHTLV-III SeronegativityHTLV-III-LAV InfectionsHomolog of Mouse T Cell and Mast Cell Growth Factor 40 GeneHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIL-9 GeneIL9IL9 geneImmune SurveillanceImmune responseImmunizeImmunologic SurveillanceImmunosurveillanceIn VitroInfectionInterleukin 9 GeneInterleukin 9 Precursor GeneIntracellular Communication and SignalingK CellsK lymphocyteKLRD1KLRD1 geneKP43Killer Cell Lectin-Like Receptor Subfamily D, Member 1 GeneKiller CellsLAV-HTLV-IIILYT3LibrariesLymphadenopathy-Associated VirusLymphocyte CytotoxicityLymphocytotoxicityLysisLytotoxicityMHC ReceptorMajor Histocompatibility Complex ReceptorMediatingMediationModern ManMolecular InteractionMonoclonal AntibodiesNK CellsNK T cellNKT cellNatural Killer CellsNatural Killer T cellNegotiatingNegotiationP40 Cytokine GeneP40 GeneP40 Protein GenePeptide antibodiesPeptidesPlayProteinsPublishingReceptor ProteinRoleSIV VaccinesSafetySalivary Gland VirusesSignal TransductionSignal Transduction SystemsSignalingSpecificityStructureT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell receptor based immunotherapyT cell receptor cellular immunotherapyT cell receptor engineered therapyT cell receptor immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cells for CART cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell ActivationT-Cell Antigen ReceptorsT-Cell Growth Factor P40 GeneT-Cell ReceptorT-Cell Receptor TherapyT-Cell Receptor TreatmentT-Cell Receptor based TherapyT-Cell Receptor based TreatmentT-Cell/Mast Cell Growth Factor P40 GeneT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTCR T cell immunotherapyTCR T cell therapyTCR TherapyTCR based T cell immunotherapyTCR based TherapyTCR based immune therapyTCR based immunotherapyTCR based treatmentTCR immunotherapyTestingTissuesViralVirusVirus-HIVYeastsactivate T cellsadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyantibody dependent cell mediated cytotoxicityantibody dependent cytotoxicityantibody mediated cellular cytotoxicityantibody-dependent cell cytotoxicityantibody-dependent cellular cytotoxicityantibody-mediated cytotoxicityantigen antibody affinityartificial intelligence modelartificial intelligence-based modelautoimmune reactivityautoreactivitybalancebalance functionbiological signal transductionbone marrow liver and thymus micebone marrow liver and thymus mousebone marrow liver and thymus transplanted micebone marrow liver and thymus transplanted mousecell assaycell based interventioncell killingcell mediated cytotoxicitycell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychallenge in rhesus macaqueschimeric antigen T cell receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellscomplementationcomputational modelingcomputational modelscomputer based modelscomputerized modelingcross reactivitycytomegalovirus groupcytotoxicitydesigndesigningdevelop therapydevelopmentalengineered T cellsexpectationgene repair therapygene therapygene-based therapygenetic therapygenetically engineered T-cellsgenomic therapyhost responseimmune system responseimmunoresponseimprovedin vitro testingin vivoinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesintervention developmentmAbsmodel of animalmonoclonal Absmouse modelmurine modelnatural killer T lymphocytenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachprogramsreceptorrhesus challengerhesus macaque challengerhesus monkey infectionscreeningscreeningsside effectsimian immunodeficiency virus vaccinessocial rolesuccesstherapeutic T-cell platformtherapy developmentthymus derived lymphocytetransgenic T- cellstreatment developmentvector
Description preview
ABSTRACT
Natural Killer (NK) cells and CD8+ T cells play critical roles in immune surveillance, and their activity is mediated
by a balance of stimulatory and inhibitory signals. The NKG2A/CD94 heterodimeric inhibitory receptor, found on
subsets of NK cells and CD8+ T cells, interacts with the non-classical HLA class Ib molecule HLA-E to limit NK…
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