grant
Project 2 - Becker
Organization UNIVERSITY OF NEW ENGLANDLocation BIDDEFORD, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026Alternative TherapiesAlternative interventionAutoregulationBindingBone DensityBone FormationBone Mineral DensityBone ResorptionBone necrosisBone remodelingCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCritical PathsCritical PathwaysDataDevelopmentEventFamilyFractureFutureGDP Dissociation FactorGDP Dissociation StimulatorsGDP Exchange FactorsGDP-GTP Exchange ProteinGDP-GTP Reversing FactorsGTP GDP exchange factorGTP PhosphohydrolasesGTPasesGenesGoalsGuanine Nucleotide Exchange FactorsGuanine Nucleotide Exchange ProteinGuanine Nucleotide Releasing FactorsGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesGuanyl-Nucleotide Exchange FactorGuanyl-Nucleotide Releasing FactorHomeostasisIn VitroIntracellular Communication and SignalingJawKnowledgeLeadLigandsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMolecularMolecular InteractionMonomeric G-ProteinsMonomeric GTP-Binding ProteinsNervous SystemNeurologic Body SystemNeurologic Organ SystemOsteoblastsOsteoclastic Bone LossOsteoclastsOsteogenesisOsteonecrosisOsteoporosisPTH geneParathyrinParathyroid HormonePathway interactionsPatient CompliancePatientsPb elementPhosphorylationPhysiological HomeostasisPlayProgenitor CellsProtein PhosphorylationProteinsRNA SeqRNA sequencingRNAseqRecommendationRegulationResearchRisk FactorsRoleRouteSafetySignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSmall G-ProteinsSmall GTPasesSubcellular ProcessTestingTherapeuticTransgenesWNT Signaling PathwayWNT signalingWorkaging associated diseaseaging associated disordersaging related diseaseaging related disordersbiological signal transductionbonebone fracturebone massbone metabolismbone preservationbone qualitybone tissue formationbone turnovercostdesigndesigningdevelopmentaldisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingexchange factorexperimentexperimental researchexperimental studyexperimentsextracellularguanosinetriphosphataseheavy metal Pbheavy metal leadhigh riskhormonal signalshormone signalsin vivoinnovateinnovationinnovativemineralizationmouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetosteoblast cell differentiationosteoblast differentiationosteoblast progenitorosteoblast stem cellosteoblastic differentiationosteogenic progenitorosteogenic stem cellosteoprogenitorosteoprogenitor cellparathormonepathwaypatient adherencepatient cooperationpreventpreventingrhorho G-Proteinsrho GTP-Binding Proteinsrho GTPasesrho Protein P21rho Small GTP-Binding Proteinsside effectsocial rolesocietal costsstem cellssubcutaneoussubdermaltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettranscriptome sequencingtranscriptomic sequencingtransgene
Description preview
PROJECT SUMMARY
Osteoporosis, or low bone mineral density, is a common disease of aging resulting in 2.3 million fractures every year with
an annual societal cost of over $57 billion. First-line treatments for osteoporosis preserve bone mineral density by
inhibiting resorption in osteoclasts, resulting in an overall decrease in bone resorption and…
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