grant
Project 2
Organization LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTERLocation TORRANCE, UNITED STATESPosted 1 Jul 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20252-Deoxy-D-glucose2-Deoxyglucose2-Desoxy-D-glucose2-deoxy-D-arabino-hexoseAffectAlbuminsAlveolar MacrophagesB220Basal Transcription FactorBasal transcription factor genesBindingBiological MarkersBiopsyBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood SerumCD45Cell BodyCell WallCellsClinicalComplexCytokine Signal TransductionCytokine SignalingDataDecision MakingDefectDeoxyglucoseDevelopmentDiagnosisDiagnosticDiseaseDisease ManagementDisorderDisorder ManagementDrugsDysfunctionEvaluationExtracellular SpaceFDA approvedFree Fatty AcidsFunctional disorderFungal SporesFungal ToxinsGM-CSFGP180General Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGeneticGerminationGlycansGlycolysisGoalsGranulocyte-Macrophage Colony-Stimulating FactorGrowthHIF 1 alphaHIF-1alphaHIF1-AlphaHIF1AHIF1A geneHIF1αHistamine-Producing Cell-Stimulating FactorHost DefenseHumanImmuneImmune EvasionImmune Modulation TherapyImmune RegulatorsImmune responseImmune systemImmunesImmunityImmunologic ModelImmunologic TechnicsImmunologic TechniquesImmunological ModelsImmunological TechnicsImmunological TechniquesImmunomodulatorsInfectionIngestionIntercellular SpaceIntermediary MetabolismKO miceKnock-out MiceKnockout MiceLY5LecithinasesLipidsLungLung Respiratory SystemMOP1MacrophageMarrow NeutrophilMediatingMedicationMelaninsMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMolecularMolecular Dynamics SimulationMolecular FingerprintingMolecular InteractionMolecular ProfilingMolgramostinMucorMucoralesMucormycosisMurineMusMycotoxinsMφNeutrophilic GranulocyteNeutrophilic LeukocyteNonesterified Fatty AcidsNull MouseNutritional ImmunityOutcomeOxidative PhosphorylationOxidative Phosphorylation PathwayPTPRCPTPRC genePathogenesisPathogenicity FactorsPatientsPhagocytesPhagocytic CellPharmaceutical PreparationsPhospholipasePhysiologicPhysiologicalPhysiopathologyPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPolysaccharidesPredispositionProcessProductionPropertyPulmonary MacrophagesRNA SeqRNA sequencingRNAseqReporterReproduction sporesRoleSerumSerum AlbuminShapesSortingSporesSusceptibilityT200TC-GM-CSFTherapeuticTissue GrowthTissue imagingToxinTranscription Factor Proto-OncogeneTranscription factor genesTumor-Cell Human GM Colony-Stimulating FactorValidationVirulenceVirulence FactorsZygomycosisaerobic glycolysisamebocytebio-markersbiologic markerbiomarkerclinical relevanceclinically relevantcytokinedevelopmentaldisease modeldisorder modeldrug/agentfat metabolismfungushost responseimmune evasiveimmune modulatorsimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune system responseimmune-modulation treatmentimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory moleculesimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatorimmunoregulatory moleculesimmunoregulatory therapyimmunoregulatory treatmentimmunoresponsein vivoingestinhibitorlipid mediatorlipid metabolismmolecular dynamicsmolecular profilemolecular signaturemutantneutrophilnew markernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel biomarkernovel markernovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathophysiologypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypesprognosticationprogramsprospectiveresponserisk stratificationscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestratify risktherapeutic immunomodulationtherapeutic immunoregulationtranscription factortranscriptome sequencingtranscriptomic sequencingtranscriptomicsuptakevalidations
Description preview
PROJECT SUMMARY/ABSTRACT
Mucormycosis (MCM) affects an expanding range of patients with unique immunometabolic abnormalities. Un-
derstanding the molecular mechanisms of host-fungal metabolic interplay is an unmet priority for development
of new therapeutic approaches against MCM. Professional phagocytes, mainly alveolar macrophages (AMs) and…
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