grant
Project 1 Mechanistic Project
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 8 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025A baumanniA baumanniiA. baumanniA. baumanniiA.baumanniiAcinetobacter baumanniAcinetobacter baumanniiAcylationAffinityAlkynesAminoglycosidesAntibiotic AgentsAntibiotic DrugsAntibioticsAssayAzidesBacteriaBacterial PneumoniaBinding ProteinsBioassayBiochemicalBiological AssayBiologyCategoriesCell BodyCell Membrane PermeabilityCell WallCellsCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)Cessation of lifeChemical StructureChemicalsClinicalCollectionColorConfocal MicroscopyContinuous InfusionDataData BasesData SetDatabasesDeathDevelopmentDoseEnzyme GeneEnzymesFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryG24 proteinGeneralized GrowthGenerationsGoalsGrowthIn VitroInfectionK pneumoniaeK. pneumoniaeKineticsKlebsiella pneumoniaeKnock-outKnockoutLabelLactamsLibrariesLigand Binding ProteinLigand Binding Protein GeneMath ModelsMembraneMiceMice MammalsMiscellaneous AntibioticModelingMolecularMorphologyMurineMusNew AgentsOutcomePatientsPatternPenetrationPenicillanic Acid SulfonePenicillin-Binding ProteinsPharmacologyPhasePolymyxinsPopulationPredispositionPreventionProtein BindingProtein Synthesis AntagonistsProtein Synthesis InhibitionProtein Synthesis InhibitorsProteinsProteomicsPublishingReceptor ProteinResistanceResuscitationReverse engineeringSeriesSiteSortingStructureSulbactamSuperbugSusceptibilitySystemTimeTissue GrowthTopoisomerase InhibitorsUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionVDAC1VDAC1 geneValidationVentilatorattributable deathattributable mortalitybacteria pneumoniabeta lactam antibioticbeta lactam hydrolasebeta-Lactamasebeta-Lactamhydrolasebeta-Lactamsbound proteincarbapenem resistancecarbapenem resistantclinical relevanceclinically relevantcombatdata basedensitydevelopmentalefflux pumpflow cytophotometryin silicoinhibitorinnovateinnovationinnovativeinsightmathematic modelmathematical modelmathematical modelingmembrane permeabilitymembrane structurenext generationnovelontogenyoverexpressoverexpressionpathogenpore forming proteinporinpreventpreventingprospectiveprotein expressionprototypereceptorresistance against carbapenemsresistance in K pneumoniaeresistance in K. pneumoniaeresistance in Klebsiella pneumoniaeresistance mechanismresistance to carbapenemresistantresistant K pneumoniaeresistant K. pneumoniaeresistant Klebsiella pneumoniaeresistant mechanismresistant to carbapenemresponsesimulationtranscriptomicsvalidationsβ lactam antibioticβ-Lactamaseβ-Lactams
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Project Summary/Abstract Project #1
Acinetobacter baumannii (AB) and Klebsiella pneumoniae (KP) are bacterial “superbugs” listed in the highest
threat category (‘Urgent’) by the United States Centers for Disease Control and Prevention. Globally, more than
100,000 deaths per year are attributable to resistance in carbapenem-resistant isolates (i.e.…
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