grant
Project 1: Immunogen Design and Delivery
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 1 Jun 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AIDS VaccinesAIDS VirusAIDS vaccineAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAffinityAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody AffinityAntibody ResponseAntigenic DeterminantsAntigensApicalB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBiologyCell LineageConsensusDevelopmentDirected Molecular EvolutionElementsEngineeringEnv trimerEpitopesExclusionExhibitsFailureGerm LinesGlycansGrantHIVHIV EnvHIV InfectionsHIV envelopeHIV envelope proteinHIV glycoprotein EnvHIV vaccineHIV viral infectionHIV virus infectionHIV-1HIV-1 EnvHIV-1 envelopeHIV-1 glycoprotein EnvHIV-1 infectionHIV-1 vaccineHIV-IHIV/AIDS VaccinesHIV1HIV1 vaccineHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Ig Somatic HypermutationImmunizationImmunoglobulin Gene RearrangementImmunoglobulin Somatic HypermutationIn VitroInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1KI miceKnock-in MouseLAV-HTLV-IIILaboratoriesLymphadenopathy-Associated VirusMemory B CellMemory B-LymphocyteMethodsModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryPeptidesPolishesPolysaccharidesPropertyRegimenResearch DesignSHIVSchemeSiteStructureStudy TypeSurfaceT cell responseTestingTimeTranslatingVaccinationVaccine DesignVaccine ResearchVaccinesVariantVariationVirus ReplicationVirus-HIVWorkantigen antibody affinitychallenge in rhesus macaquesconformationconformationalconformational stateconformationallyconformationsdesigndesigningdevelopmentaldirected evolutionevaluate vaccineshuman immunodeficiency virus infectionhuman immunodeficiency virus vaccineimmunogenin vivoinfected rhesus macaquesinfected rhesus monkeyinfected with HIVinfected with human immunodeficiency virusinfection in rhesus macaquesinfection of rhesus macaquesknockin micemodel of animalmouse modelmultiomicsmultiple omicsmurine modelneutralizing antibodynew approachesnovelnovel approachesnovel strategiesnovel strategypanomicspre-clinical trialpreclinical trialpreventpreventingrational designresponserhesus challengerhesus macaque challengerhesus monkey infectionsimian HIVsimian human immunodeficiency virussomatic hypermutationstudy designtoolvaccine against HIVvaccine against HIV-1vaccine antibodiesvaccine evaluationvaccine induced antibodiesvaccine platformvaccine screeningvaccine strategyvaccine testingvaccine-induced antibodiesvaccine-related researchviral multiplicationviral replicationvirus multiplication
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PROJECT SUMMARY/ABSTRACT
The development of an effective HIV vaccine remains a major challenge. Previous strategies for HIV vaccine
design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutralizing antibodies
(bnAbs), or some combination of the three but have failed to protect against infection. There is a…
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