grant
Project 1: Immunogen Design and Delivery
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 1 Jun 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAffinityAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody AffinityAntibody ResponseAntigenic DeterminantsAntigensApicalB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBiologyCell LineageConsensusDevelopmentDirected Molecular EvolutionElementsEngineeringEpitopesExclusionExhibitsFailureGerm LinesGlycansGrantHIVHIV envelopeHIV envelope proteinHIV vaccineHIV-1HIV-1 vaccineHIV-IHIV/AIDS VaccinesHIV1HIV1 vaccineHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Ig Somatic HypermutationImmunizationImmunoglobulin Gene RearrangementImmunoglobulin Somatic HypermutationIn VitroInfectionKI miceKnock-in MouseLAV-HTLV-IIILaboratoriesLymphadenopathy-Associated VirusMemory B CellMemory B-LymphocyteMethodsModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryPeptidesPolishesPolysaccharidesPropertyRegimenResearch DesignSHIVSchemeSiteStructureStudy TypeSurfaceT cell responseTestingTimeTranslatingVaccinationVaccine DesignVaccine ResearchVaccinesVariantVariationVirus ReplicationVirus-HIVWorkantigen antibody affinitychallenge in rhesus macaquesconformationconformationalconformational stateconformationallyconformationsdesigndesigningdevelopmentaldirected evolutionevaluate vaccineshuman immunodeficiency virus vaccineimmunogenin vivoinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesknockin micemodel of animalmouse modelmultiomicsmultiple omicsmurine modelneutralizing antibodynew approachesnovelnovel approachesnovel strategiesnovel strategypanomicspre-clinical trialpreclinical trialpreventpreventingrational designresponserhesus challengerhesus macaque challengerhesus monkey infectionsimian HIVsimian human immunodeficiency virussomatic hypermutationstudy designtoolvaccine antibodiesvaccine evaluationvaccine induced antibodiesvaccine platformvaccine screeningvaccine strategyvaccine testingvaccine-induced antibodiesvaccine-related researchviral multiplicationviral replicationvirus multiplication
Description preview
PROJECT SUMMARY/ABSTRACT
The development of an effective HIV vaccine remains a major challenge. Previous strategies for HIV vaccine
design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutralizing antibodies
(bnAbs), or some combination of the three but have failed to protect against infection. There is a…
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