grant
Project 1: Deciphering the Dynamic Evolution of the Tumor-Neural Interface
Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 15 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AMPA ReceptorsAbscissionAffectAfter CareAfter-TreatmentAftercareAnimalsAnti-epilepticBiological FunctionBiological ProcessBlood VesselsBody TissuesBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell LocomotionCell MigrationCell MovementCell SignalingCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular ExpansionCellular GrowthCellular MigrationCellular MotilityClassificationClinical TrialsClone CellsCommunicationCommunitiesCompetenceComputer ModelsComputerized ModelsDataDedicationsDevelopmentECMElectrophysiologyElectrophysiology (science)EncephalonExcisionExhibitsExtirpationExtracellular MatrixFavorable Clinical OutcomeGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGlutamatesGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHeterogeneityHigh Frequency OscillationImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualIntracellular Communication and SignalingInvadedL-GlutamateLevetiracetamLocationLogistic RegressionsMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignantMalignant - descriptorMalignant Glial NeoplasmMalignant Glial TumorMalignant GliomaMalignant Neuroglial NeoplasmMalignant Neuroglial TumorMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic PathwayMicroscopicMitochondriaModelingMolecularMultiomic DataNMR ImagingNMR TomographyNatureNerve CellsNerve UnitNeural CellNeural NeoplasmNeural TumorNeurocyteNeuroepithelial, Perineurial, and Schwann Cell NeoplasmNeuroglial NeoplasmNeuroglial TumorNeuronsNeurophysiology / ElectrophysiologyNuclear Magnetic Resonance ImagingOncogenesisOperative ProceduresOperative Surgical ProceduresOxidative PhosphorylationOxidative Phosphorylation PathwayPDX modelPathway interactionsPatient derived xenograftPatientsPhenotypeProliferatingRadiation therapyRadiotherapeuticsRadiotherapyRecurrenceRecurrentRemovalResearch ResourcesResearch SpecimenResectedResistanceResolutionResourcesRouteSamplingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSliceSpecimenSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSynapsesSynapticSystemSystematicsSystems BiologyTM-MKRTestingTherapeuticTimeTissuesTreatment EfficacyTumor CellTumor MarkersTumor PromotionWorkZeugmatographyanti-epileptic agentsanti-epileptic drugsbiological signal transductioncancer cell metabolismcancer metabolismcancer progressioncancer proteomicscell growthcell motilitycell typechemotherapyclinical relevanceclinically relevantcohortcomputational modelingcomputational modelscomputer based modelscomputerized modelingdata integrationdeep learningdeep learning methoddeep learning strategydesigndesigningdevelopmentaldynamical evolutionelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsglial-derived tumorglioblastoma multiformeglutamatergicin vivoinhibitorinnovateinnovationinnovativeintervention efficacymitochondrialmultiomicsmultiple omic datamultiple omicsneoplasm progressionneoplastic cellneoplastic progressionneuroglia neoplasmneuroglia tumorneuronalneuronal tumornovelpanomicspathwaypatient derived xenograft modelpharmacologicpost treatmentpre-clinicalpreclinicalprogenitorradiation treatmentrandom forestresectionresistance to therapyresistantresistant to therapyresolutionsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspongioblastoma multiformestandard of caresubstantia albasurgerysynapsetherapeutic agent developmenttherapeutic developmenttherapeutic efficacytherapeutic resistancetherapy efficacytherapy resistanttreatment resistancetreatment with radiationtumortumor biomarkertumor cell metabolismtumor metabolismtumor progressiontumor specific biomarkertumorigenesistumors in the brainvascularwhite matter
Description preview
ABSTRACT – PROJECT 1
The central premise of our CSBC MIT/DFCI Center for Systems Biology in Glioblastoma is that high-content
systems-level measurements at molecular, microscopic, and macroscopic scales with spatial resolution will
enable the development of computational models to map and predict tumor dynamics leveraging data integration
and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click