grant
Project 1-Cohort/Ethics Study of Patients with Severe Alcoholic Hepatitis undergoing Early Liver Transplantation
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Feb 2019Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AccountingActive Follow-upAcuteAddressAdmissionAdmission activityAffectAlcohol DrinkingAlcohol associated hepatitisAlcohol consumptionAlcohol dependenceAlcohol hepatitisAlcohol induced hepatitisAlcohol related hepatitisAlcoholic HepatitisAlcoholic Liver DiseasesAreaBioethicsBiomedical EthicsCaringCessation of lifeClinicalCommunitiesConsensusDataDeathDeath RateDecrease disparityDevelopmentDiagnosisEconomic IncomeEconomical IncomeEnsureEquityEtOH drinkingEtOH useEthanol-induced hepatitisEthicsEvaluationFutureGeneral PopulationGeneral PublicGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGeographyGoalsGrantGroups at riskHealth Care ProfessionalHealth Catchment AreaHealth ProfessionalHealth Service AreaHepatic TransplantationIncomeIndividualInferiorInformed ConsentInfrastructureInsuranceInterventionLifeLiteratureLiver GraftingLiver TransplantLower disparityMeasuresMedicalNIAAANational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthNeighborhoodsNon-HispanicNonhispanicNot Hispanic or LatinoOutcomeOutcome AssessmentPatient CarePatient Care DeliveryPatient advocacyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPeople at riskPerceptionPersons at riskPhasePhenX ToolkitPhenotypes and eXposures ToolkitPhenxPilot ProjectsPoliciesPopulationPopulations at RiskPrivatizationProcessProspective cohortProspective, cohort studyProviderQOCQuality of CareReactionRecommendationRefractoryRelapseResearchResearch ResourcesResolutionResourcesSelection CriteriaService areaSocioeconomically disadvantagedSpecialistSubstance Use DisorderTransplant RecipientsTransplantationUnited StatesUnited States National Institutes of HealthUniversitiesVulnerable PopulationsWaiting ListsWorkaccess disparitiesaccess gapsaccessibility disparitiesactive followupalcohol addictionalcohol dependencyalcohol dependentalcohol induced hepatic injuryalcohol induced liver disorderalcohol induced liver injuryalcohol ingestionalcohol intakealcohol product usealcohol related liver diseasealcohol related researchalcohol researchalcohol usealcohol-associated liver diseasealcohol-induced hepatic dysfunctionalcohol-induced liver diseasealcohol-induced liver dysfunctionalcohol-mediated liver dysfunctionalcohol-mediated liver injuryalcohol-related liver diseasealcoholic beverage consumptionalcoholic drink intakealcoholic liver injurycandidate selectioncare for patientscare of patientscare outcomescaring for patientscohortdeprivationdevelopmentaldisparities in accessdisparity reductiondrinkingethanol consumptionethanol drinkingethanol induced hepatic injuryethanol induced liver disorderethanol induced liver injuryethanol ingestionethanol intakeethanol liver diseaseethanol product useethanol researchethanol useethanol-induced hepatic dysfunctionethanol-induced liver diseaseethanol-induced liver dysfunctionethanol-mediated liver dysfunctionethanol-mediated liver injuryethicalevidence baseexperiencefollow upfollow-upfollowed upfollowupgaps in accessgeographic sitehealth care outcomeshospital servicesimprovedincomesindexinginequality in accessinequity in accessinequity in accessibilityinterdisciplinary approachliver transplantationmethods to study multiple-level influencesmitigate disparitymortalitymortality ratemortality ratiomulti-level analysismulti-level modelmultidisciplinary approachmultilevel analysismultilevel modelmultilevel modelingnewsnovelparticipant enrollmentpatient enrollmentpatient oriented outcomespatient populationpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespilot studypost-transplantpost-transplantationposttransplantposttransplantationreduce disparityreduction in disparityresolutionsresponsesobersobrietysocial health determinantssocial mediasocio-demographic factorssocio-economicsocio-economic disadvantagesocio-economicallysocio-economically disadvantagedsocio-economically underprivilegedsociodemographic factorssocioeconomic disadvantagesocioeconomicallysocioeconomically underprivilegedsocioeconomicssubstance use and disordersuccesstransplanttransplant centerstransplant patientvulnerable groupvulnerable individualvulnerable peoplewaitlist
Description preview
Project Summary
In 2021, Alcoholic Liver Disease (ALD) accounted for 37% of liver transplants (LTs) performed in the United
States. Given concerns for relapse in alcohol use post-transplant, most centers require that candidates have
been abstinent from alcohol use for 6-months prior to being placed on the waitlist for transplant. However, a
subset…
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