grant
Project 1 - Cognitive Function and Dementia
Organization HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTHLocation BOSTON, UNITED STATESPosted 15 Sept 2013Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years oldAD related dementiaADRDAddressAffectAfrica South of the SaharaAfricanAge YearsAgingAlgorithmsAlzheimer risk factorAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAstroproteinBiologicalBiological MarkersBirthBloodBlood PlasmaBlood Reticuloendothelial SystemCalibrationCategoriesCharacteristicsChildChild YouthChildren (0-21)CognitionCognitiveCognitive ManifestationsCognitive SymptomsCollaborationsCommunitiesConsensusCountryCredentialingDataDementiaDiagnosisEconomic IncomeEconomical IncomeEducationEducational aspectsEducational process of instructingEpidemiological dataEpidemiologyEpidemiology dataGFA-ProteinGFAPGenerationsGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsHealthHealth and Retirement StudyHealth systemIncidenceIncomeInternationalLMICLinguisticLinguisticsLived experienceLived experiencesLongitudinal StudiesMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMagnetic Resonance ImagingMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceNMR ImagingNMR TomographyNerve DegenerationNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeurobiologyNeuron DegenerationNeuropsychologic TestsNeuropsychological TestsNeuropsychologiesNeuropsychologyNuclear Magnetic Resonance ImagingOutcomeParentsParticipantParturitionPathway interactionsPatternPerformancePhenotypePlasmaPlasma SerumPopulationPopulation StudyPrevalencePreventative strategyPrevention strategyPreventive strategyProtocolProtocols documentationPsychometricsResearchResearch ResourcesResourcesRespondentReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleSamplingSeveritiesShapesSisterSocial ChangeSocial ConditionsSocial NetworkSocial modificationSocial supportSocial transformationSocietal ConditionsSouth AfricaSouth AfricanSub-Saharan AfricaSubsaharan AfricaSurvey InstrumentSurveysSymptomsTeachingTechniquesTranslatingValidity and ReliabilityVariantVariationWomanWorkZeugmatographyaged brainaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging brainaging populationalzheimer riskbio-markersbiologicbiologic markerbiomarkerblood-based biomarkerblood-based markercognitive assessmentcognitive changecognitive functioncognitive reservecognitive testingcohortdata harmonizationdementia riskdiagnostic algorithmepidemiologicepidemiologic dataepidemiologicalexperienceglobal healthharmonized dataincomesinformal educationinformal instructioninformal learninginnovateinnovationinnovativeinsightkidslate in lifelate lifelater in lifelater lifelife historyliteracylong-term studylongitudinal outcome studieslow and middle-income countriesmagnetic resonance imaging biomarkermagnetic resonance imaging markermenmild cognitive disordermild cognitive impairmentneural degenerationneural imagingneuro-imagingneurobehavioral symptomneurobiologicalneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropathologicneuropathologicalneuropathologyneuropsychologicnovelolder adultolder adulthoodp-taup-τparentpathwayphospho-tauphospho-τphosphorylated taupopulation agingpopulation-based studypopulation-level studypost-translational modification of tauposttranslational modification of taurisk factor for dementiarisk for dementiaskillssocialsocial determinantssocial factorssocial rolesocial support networksociodeterminantstudies of populationsstudy of the populationtau phosphorylationtau posttranslational modificationtau-1youngsterτ phosphorylation
Description preview
Project 1: Cognitive Function and Dementia—Abstract
The greatest impact of Alzheimer’s disease and related dementias (ADRD) is likely to be experienced in low-
and middle-income countries (LMICs). Sub-Saharan Africa, in particular, is projected to encounter a dramatic
increase in dementia prevalence and there is a growing need for rigorous…
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