grant

Project 1 - Balog

Organization UNIVERSITY OF NEW ENGLANDLocation BIDDEFORD, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20261-Phosphatidylinositol 3-KinaseAccelerationAcuteAgingAmputationAngiogenesis AntagonistsAngiogenesis BlockersAngiogenesis FactorAngiogenesis InhibitorsAngiogenetic AntagonistsAngiogenetic InhibitorsAngiogenic AntagonistsAngiogenic FactorAngiogenic InhibitorsAngiostatic AgentsAnti-Angiogenetic AgentsAnti-Angiogenic AgentsAnti-Angiogenic DrugsAntiangiogenesis AgentsAntiangiogenic AgentsAntiangiogenic DrugsBandageBindingBiochemicalBiocompatible MaterialsBiologicalBiomaterialsBiopolymersBiotechBiotechnologyBlood VesselsBlood flowBody TissuesCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCessation of lifeChemistryChronicClinicalCo-cultureCocultivationCocultureCoculture TechniquesConfusionConfusional StateDangerousnessDataDeathDevelopmentDiabetes MellitusDrug TargetingDrugsElastinElderlyEndothelial CellsEngineeringEnvironmentEventExposure toFLK1FLT VEGF ReceptorFLT1 RTKFLT1 Receptor Tyrosine KinaseFailureFlt-1FutureGeneHomologGeneralized GrowthGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGoalsGrowthGrowth AgentsGrowth FactorGrowth Factor ReceptorsGrowth SubstancesHealing abnormalHealing delayedHealth Care CostsHealth CostsHomologHomologous GeneHomologueHydrogelsImmune responseImpaired healingImpaired tissue repairImpaired wound healingImpairmentIn VitroInflammationInflammatory ResponseIntracellular Communication and SignalingJournalsKDR geneKnowledgeLeadLigandsMacrophageMagazineMechanicsMediatingMedicationMental ConfusionMethodsModelingMolecular InteractionMorbidityNeovascularization InhibitorsObesityOtomyPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePathway interactionsPatternPb elementPeer ReviewPeptidesPersonsPharmaceutical PreparationsPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhosphorylationPlayPolymersPopulationPost-operative PainPostoperative PainProcessProgenitor CellsProliferatingPropertyProtein PhosphorylationProteins Growth FactorsProto-Oncogene Protein fltPtdIns 3-KinasePublishingQOLQuality of lifeReagentReceptor ProteinReceptor Tyrosine Kinase,Class VRecombinant DNA TechnologyRegenerative MedicineRepressionReproducibilityResearchRisk FactorsRoleSignal TransductionSignal Transduction SystemsSignalingSiteSkin wound healingSurfaceSurgical incisionsSystemTestingTherapeuticTissue EngineeringTissue GrowthTissuesTopical AntibioticType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseTyrosine Protein Kinase FRTTyrosine Protein Kinase Receptor FLTVEGFVEGF Receptor flt-1 ProteinVEGF ReceptorsVEGF-BVEGF-B VEGF-Related FactorVEGF-B VEGF-Related ProteinVEGFRVEGFR-1VEGFR-2VEGFR1VEGFR2VEGFsVPF ReceptorValidationVascular Endothelial Cell Growth Factor ReceptorVascular Endothelial Growth Factor BVascular Endothelial Growth Factor Receptor 2Vascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsVascular Permeability Factor ReceptorVegf inhibitionWound RepairWound healing therapyWound modelsabnormal tissue repairacute woundadiposityadvanced ageangiogenesisantiangiogenicbiocompatibilitybioengineered tissuebiologicbiological materialbiological signal transductionbiomaterial compatibilitybiomaterial developmentblood vessel developmentblood vessel formationcell behaviorcell typecellular behaviorchronic skin woundchronic woundclinical applicabilityclinical applicationclinical materialclinical translationclinically translatablecorpulencecutaneous wound healingdelayed wound healingdermal wound healingdesigndesigningdevelop therapydevelopmentaldiabetesdiabeticdrug/agentengineered tissueexperimentexperimental researchexperimental studyexperimentsextracellularfms-Like Tyrosine Kinasegenetically engineeredgeriatrichealingheavy metal Pbheavy metal leadhost responseimmune system responseimmunoresponseimprovedin vivoincisioninfection riskinjuredinnovateinnovationinnovativeinsightintervention developmentmechanicmechanicalmigrationmimeticsmouse modelmurine modelnanoneovascularizationnext generationnovelontogenypain after surgeryparticlepathwaypeptide mimeticpeptide mimicpeptidomimeticsphospho-proteomicsphosphoproteomicspolymerpolymericpost-surgical painpostsurgical painreceptorrecruitregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresponseresponse to therapyresponse to treatmentrevascularizationscaffoldscaffoldingself assemblysenior citizensocial rolestem cellstherapeutic responsetherapy developmenttherapy responsetissue regenerationtissue regrowthtissue renewaltissue repairtissue specific regenerationtissue woundtooltreatment developmenttreatment responsetreatment responsivenessvalidationsvascularwoundwound healingwound healing modelswound healing therapeuticswound recoverywound resolutionwoundingwounds
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Description preview

Impaired wound healing increases the risks of infection and the development of chronic wounds, which can lead to
significant morbidity and decreased quality of life, as well as increased healthcare costs. For people with additional risk

factors for chronic wounds, such as aging, diabetes, and obesity, the failure of a wound to heal properly can be…

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Project 1 - Balog — UNIVERSITY OF NEW ENGLAND | UNITED STATES | Jan 2024 | Dev Procure