grant
Project-004
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 10 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAdemetionineAdoMetAffectAnti-viral TherapyAntibodiesBindingBiological FunctionBiological ProcessBlood Coagulation DisordersBrainBrain Nervous SystemCASP11CASP4CASP4 geneCOVID crisisCOVID disease severityCOVID epidemicCOVID infected patientCOVID pandemicCOVID patientCOVID positive patientCOVID severityCOVID-19COVID-19 associated cytokine stormCOVID-19 crisisCOVID-19 cytokine stormCOVID-19 disease severityCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 induced cytokine stormCOVID-19 infected patientCOVID-19 infectionCOVID-19 pandemicCOVID-19 patientCOVID-19 periodCOVID-19 positive patientCOVID-19 public health crisisCOVID-19 related cytokine stormCOVID-19 severityCOVID-19 therapyCOVID-19 treatmentCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19 virus infectionCOVID-19 yearsCOVID19 disease severityCOVID19 infectionCOVID19 patientCOVID19 positive patientCOVID19 severityCOVID19 virusCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCV-19Cas nuclease technologyCaspaseCaspase GeneCell BodyCell-Death ProteaseCellsCessation of lifeClinical TrialsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoV-2CoV2Coagulation DisorderCoagulopathyComplementComplement ProteinsCoronavirus Infectious Disease 2019Cysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesDataDeathDevelopmentDiseaseDisorderDrugsEC 2.1.1EncephalonEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEscape MutantExposure toGene ExpressionGoalsHealthHeartHigh-Throughput RNA SequencingHumanICE and CED3 Homolog 2ICE-like proteaseICH-2In VitroInflammasomeInnate Immune ResponseInnate ImmunityKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLungLung Respiratory SystemMOF syndromeMapsMediatingMedicationMethylationMethyltransferaseMiceMice MammalsModern ManModificationMolecular InteractionMouse Homolog of Caspase 11Multiple Organ Dysfunction SyndromeMultiple Organ FailureMurineMusNative ImmunityNatural ImmunityNon-Polyadenylated RNANon-Specific ImmunityNonspecific ImmunityNull MouseOrganOutcomePathogenesisPathologyPharmaceutical PreparationsPlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein ModificationProteinsPseudouridinePulmonary PathologyRNARNA Gene ProductsRNA metabolismRNA purificationRNA-Binding ProteinsReaderRibonucleic AcidRoleS-AdenosylhomocysteineS-AdenosylmethionineS-adenosyl methionineS-adenosyl-methionineSAMeSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 associated cytokine stormSARS-CoV-2 cytokine stormSARS-CoV-2 disease severitySARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 induced cytokine stormSARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 inhibitorSARS-CoV-2 pandemicSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV-2 related cytokine stormSARS-CoV-2 severitySARS-CoV-2 therapySARS-CoV-2 treatmentSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SeriesSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 inhibitorSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome related corona virus 2Short interfering RNASiteSmall Interfering RNATechniquesTherapeuticTherapeutic EffectTranslationsViralViral BurdenViral DiseasesViral LoadViral Load resultVirusVirus DiseasesVirus ReplicationWuhan coronavirusadaptive immune responseadaptive immunitybleeding disorderblock SARS-CoV-2block severe acute respiratory syndrome coronavirus 2bronchial epitheliumclotting disordercomplementationcoronavirus disease 2019coronavirus disease 2019 associated cytokine stormcoronavirus disease 2019 crisiscoronavirus disease 2019 cytokine stormcoronavirus disease 2019 disease severitycoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 induced cytokine stormcoronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 pandemiccoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 public health crisiscoronavirus disease 2019 related cytokine stormcoronavirus disease 2019 severitycoronavirus disease 2019 therapycoronavirus disease 2019 treatmentcoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease infected patientcoronavirus disease pandemiccoronavirus disease patientcoronavirus disease positive patientcoronavirus disease severitycoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientcystein proteasecystein proteinasecysteine endopeptidasecytokine release syndromecytokine stormdevelopmentaldrug/agenteffective therapyeffective treatmentepigeneticallyhCoV19improvedin vivoinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2inhibit SARS-CoV-2inhibit severe acute respiratory syndrome coronavirus 2inhibitorknock-downknockdownlife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2long-term sequelaelung pathologymembermethylasemultiorgan failuremultiple organ system failurenCoV2nano particlenano-sized particlenanoparticlenanosized particlenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetobligate intracellular parasitepatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2preventpreventingprogramsserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 associated cytokine stormsevere acute respiratory syndrome coronavirus 2 cytokine stormsevere acute respiratory syndrome coronavirus 2 disease severitysevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 induced cytokine stormsevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere acute respiratory syndrome coronavirus 2 related cytokine stormsevere acute respiratory syndrome coronavirus 2 severitysevere acute respiratory syndrome coronavirus 2 therapysevere acute respiratory syndrome coronavirus 2 treatmentsevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2shRNAshort hairpin RNAsiRNAsmall hairpin RNAsmall molecular inhibitorsmall molecule inhibitorsocial roletranslationtransmethylasetreat COVID-19treat SARS-CoV-2treat coronavirus disease 2019treat severe acute respiratory syndrome coronavirus 2variants of concernviral RNAviral infectionviral infectious disease treatmentviral multiplicationviral replicationvirus RNAvirus infectionvirus multiplicationvirus-induced disease
Description preview
Project 3: Host and viral RNA modifications and their roles in multi-organ pathologies
Abstract
The continuous emergence of SARS-CoV-2 variants of concern (VoC) and antibody and drug-escaping mutants
complicates the current COVID-19 pandemic. There is an urgent need to develop new improved antiviral
therapies for COVID-19. RNA modification is…
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